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Iranian Journal of Public Health، جلد ۴۵، شماره ۱۲، صفحات ۱۶۲۵-۱۶۳۵
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عنوان انگلیسی Association of COX-2 Promoter Polymorphisms -765G/C and -1195A/G with Migraine
چکیده انگلیسی مقاله Background: Migraine is a common debilitating primary headache disorder with current head pain attacks, which contributes to physical activity dysfunctions in chronic pain phase. PGE2 and PGI2 are two important prostaglandins synthesised by COX-2 enzymes, involved in migraine pain signals. COX-2 modulation is essential in treatment and pathogenesis of migraine. This study aimed to investigating the association between COX-2 gene polymorphisms with the risk of migraine susceptibility in migraine patients with related and unrelated parents. Methods: This case- control study was based on 100 migraine patients and 100 non-migraine subjects in Bushehr province, Iran in 2013. Genomic DNA of blood samples was extracted and genotyping of COX-2-765G > C (rs20417) and COX-2-1195A > G (rs689466) gene variants was investigated by PCR-RFLP method. Statistical analyses were accomplished using the SPSS software package. Results: There was a significant differences in the frequencies of the COX-2-765G>C and COX-2-1195A>G genotypes between migraine patients and controls ( P ≤0.05). Conclusion: COX-2-765CC , COX-2-765CG , COX-2-1195GG and COX-2-1195AG genotypes can increase the risk of migraine significantly. As the first study in Iran, we are hopeful to achieve greater results about the relevancy of COX-2 gene, migraine and pain signals pathway by repeating these experiments on more samples.
کلیدواژه‌های انگلیسی مقاله Migraine, COX-2 gene, Polymorphism, RFLP, Iran
نویسندگان مقاله الهه مظفری | elahe mozaffari


عباس دوستی | abbas doosti


اصغر عرشی | asghar arshi


مصطفی فغانی | mostafa faghani


نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/8638
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/86/article-86-313929.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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