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Avicenna Journal of Phytomedicine، جلد ۷، شماره ۱، صفحات ۳۷-۴۵
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عنوان انگلیسی Anti-inflammatory effect of Fumaria parviflora leaves based on TNF-α, IL-1, IL-6 and antioxidant potential
چکیده انگلیسی مقاله Objective: In this study, we evaluated anti-inflammatory activity of leaves of Fumaria parviflora (F. parviflora) and underlying mechanisms by using in vivo models of inflammation.Material and Methods: Albino Wistar rats of either sex weighing 150 - 200 g were used. Soxhlet ethanol and aqueous extracts of leaves of F. parviflora (EFP and AFP) were prepared. The anti-inflammatory activity was studied using carrageenan-induced paw edema method and cotton pellet granuloma method. Levels of cytokines such as TNF-α, IL-6 and IL-1 and activity of antioxidant enzymes including catalase (CAT) and glutathione peroxidase (GPx) were estimated.Results: Leaves of F. parviflora demonstrated significant (p< 0.001) decrease in paw edema in carrageenan-induced paw edema method. It diminished the serum tumour necrosis factor-α (TNF-α), IL-6 and IL-1 levels and also significantly attenuated the malondialdehyde (MDA) levels. The activity of CAT and GPx was increased in paw tissue. It also demonstrated significant decrease in granuloma formation in cotton pellet-induced granuloma method.Conclusion: Leaves of F. parviflora possess anti-inflammatory activity as they inhibit various cytokines and have antioxidant effects and free radical scavenging activity.
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نویسندگان مقاله waseem ریضوی | waseem rizvi
department of pharmacology, jawaharlal nehru medical college, aligarh muslim university, aligarh 202002, india


محمد fayazuddin | mohammad fayazuddin
department of pharmacology, raichur institute of medical sciences, raichur, 584101, india


ompal سینگ | ompal singh
chemical research unit, department of research in unani medicine, aligarh muslim university, aligarh 202002, india


shariq نعیم | shariq naeem
department of pharmacology, jawaharlal nehru medical college, aligarh muslim university, aligarh 202002, india


shagufta معین | shagufta moin
department of biochemistry, jawaharlal nehru medical college, aligarh muslim university, aligarh 202002, india


کفیل اختر | kafil akhtar
department of pathology, jawaharlal nehru medical college, aligarh muslim university, aligarh 202002, india


آنیل کومار | anil kumar
department of pharmacology, jawaharlal nehru medical college, aligarh muslim university, aligarh 202002, india
نشانی اینترنتی http://ajp.mums.ac.ir/article_6955.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/232/article-232-313967.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research Article
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