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Avicenna Journal of Phytomedicine، جلد ۷، شماره ۱، صفحات ۵۴-۶۵
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عنوان انگلیسی Ginger extract modulates the expression of IL-12 and TGF-β in the central nervous system and serum of mice with experimental autoimmune encephalomyelitis
چکیده انگلیسی مقاله Objective: The main function of IL-12 is differentiation of naive T cells intoTh1 cells and TGF-β is a powerful immunoregulatory cytokine. The immunomodulatory and anti-inflammatory properties of ginger have also been reported in some studies. The aim of this study was to evaluate the effects of ginger extract on the expression of IL-12 and TGF-β in a model of experimental autoimmune encephalomyelitis (EAE).Materials and Methods: EAE was induced in C57BL/6 mice by immunization with myelin oligodendroglial glycoprotein emulsified in complete Freund's adjuvant. The mice were administered intra-peritoneally with ginger extracts or PBS, from day +3 to +30. On day 31, mice were scarified and the expression of IL-12 and TGF-β mRNA in the spinal cord were determined by using real time-PCR. The serum levels of cytokines were measured by ELISA.Results: In PBS-treated EAE mice, the expression of IL-12 P35 and IL-12 P40 mRNA in the CNS and the mean serum levels of IL-12 were significantly higher than those of healthy group (p< 0.001). In ginger-treated EAE mice, the expression of IL-12 mRNA and its serum levels were significantly lower as compared to PBS-treated EAE mice. No significant difference was observed between PBS-treated EAE mice and healthy group regarding the expression of TGF-β mRNA. In ginger (300 mg/kg)-treated EAE group, the expression of TGF-β mRNA and its serum levels were significantly higher in comparison to PBS-treated EAE mice (p Conclusion: These results indicated that ginger extract modulates the expression of IL-12 and TGF-β in CNS and serum of EAE mice.
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نویسندگان مقاله عبدالله جعفرزاده | abdollah jafarzadeh
department of immunology, medical school, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

ریحانه آهنگر پروین | rayhane ahangar parvin
department of immunology, medical school, rafsanjan university of medical sciences, rafsanjan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

مریم نعمتی | maryam nemati
neuroscience research center, institute of neuropharmacology, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

زهرا تقی پور | zahra taghipour
department of histology, medical school, rafsanjan university of medical sciences, rafsanjan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

علی شمسی زاده | ali shamsizadeh
department of physiology, medical school, rafsanjan university of medical sciences, rafsanjan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

فاطمه ایوبی | fatemeh ayoobi
department of physiology, medical school, rafsanjan university of medical sciences, rafsanjan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

زهیر حسن | zuhair hassan
department of immunology, medical school, tarbiat moddares university, tehran, iran
نشانی اینترنتی http://ajp.mums.ac.ir/article_7002.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/232/article-232-313969.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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