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Avicenna Journal of Phytomedicine، جلد ۷، شماره ۱، صفحات ۷۳-۷۹
عنوان فارسی
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عنوان انگلیسی Antinociceptive effect of extracts of Marrubium astracanicum Jacq. aerial parts
چکیده انگلیسی مقاله Objective: The genus Marrubium is used for treatment of joint pain, gout, stomach-ache and colic in Iranian Traditional Medicine. Marrubium astracanicum Jacq. (M. astracanicum) is a native species in the flora of Iran. The aim of this study was to evaluate the antinociceptive properties of various extracts of aerial parts of M. astracanicum.Materials and Methods: Antinociceptive activities of total hydroalcoholic extract (THE) and its n-hexane (non-polar) and residual partition (polar) fractions were analyzed using formalin test in mice. Morphine (5 mg/kg) and normal saline were used as positive and negative controls, respectively.Results: Intraperitoneal administration of THE (50, 100 and 200 mg/kg), non-polar fraction (200 mg/kg) and polar fraction (100 and 200 mg/kg), 30 min before formalin injection, caused significant analgesic activity in acute phase (0-5 min after formalin injection) of formalin test (p0.05 in comparison with morphine). In chronic phase (15–60 min after formalin injection), non-polar and polar fractions (50, 100 and 200 mg/kg) showed significant analgesic activity (p0.05 in comparison with morphine).Conclusion: Different extracts of M. astracanicum demonstrated antinociceptive activity that support the traditional usage of Marrubium genus for the treatment of arthritis, gout and other inflammatory diseases.
کلیدواژه‌های انگلیسی مقاله Marrubium astracanicum, Pain measurment, Analgesic
نویسندگان مقاله نیلوفر کهکشانی | niloofar kahkeshani
department of pharmacognosy, faculty of pharmacy and persian medicine and pharmacy research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

میلاد قره داغی | milad gharedaghi
department of pharmacognosy, faculty of pharmacy and persian medicine and pharmacy research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

عباس حاجی آخوندی | abbas hadjiakhoondi
departments of pharmacognosy and medicinal plants research center, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد شریف زاده | mohammad sharifzadeh
departments of pharmacology and toxicology and pharmaceutical sciences research center, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مهناز خانوی | mahnaz khanavi
faculty of land and food systems, university of british columbia, b.c., canada
نشانی اینترنتی http://ajp.mums.ac.ir/article_7073.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/232/article-232-313971.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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