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Middle East Journal of Cancer، جلد ۸، شماره ۱، صفحات ۷-۰
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عنوان انگلیسی Association of Glutathione S-transferase Genes (M1 and T1) with the Risk of Acute Myeloid Leukemia in a Moroccan Population
چکیده انگلیسی مقاله Background: Acute myeloid leukemia, as most cancers, results from exposure to carcinogens and an impaired inherited individual capacity to eliminate xenobiotics. The present case-control study measures the relationship between glutathione S-transferase (GST) T1 and M1 null genotypes and the risk of acute myeloid leukemia. Methods: We identified the GSTT1 andGSTM1 genotypes by multiplex polymerase chain reaction in 129 acute myeloid leukemia patients and 129 controls. Results: Individuals that carried GSTT1 null had a risk of acute myeloid leukemia when compared to GSTT1 present carriers (OR: 2.80; 95% CI: 1.63-4.80, P=0.00036). However, GSTM1 null did not influence the risk for acute myeloid leukemia (OR: 1.20; 95% CI: 0.72-1.97, P=0.53). The combined GSTT1 null/GSTM1 present genotype showed an association with the risk for acute myeloid leukemia compared to those that carried both functional genotypes (OR: 8.85; 95% CI: 3.09-23.8, P=0.0001). The double null genotype also showed an association with the risk for acute myeloid leukemia (OR: 2.32, 95% CI: 1.15-4.66, P=0.019). Conclusion: Both GSTT1 null and GST double-null genotypes may be risk factors for acute myeloid leukemia. Further studies are needed to confirm these results.
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نویسندگان مقاله ait boujmia oum kaltoum | ait boujmia oum kaltoum
laboratory of genetics and molecular pathology, medical school, university hassan ii, casablanca, morocco


nadifi sellama | nadifi sellama
laboratory of genetics and molecular pathology, medical school, university hassan ii, casablanca, morocco


dehbi هند | dehbi hind
laboratory of genetics and molecular pathology, medical school, university hassan ii, casablanca, morocco


kassogue یحیی | kassogue yaya
laboratory of genetics and molecular pathology, medical school, university hassan ii, casablanca, morocco


المشاهب مونا | lamchahab mouna
department of onco-hematology, ibn rochd university hospital, casablanca, morocco


قسار اسما | quessar asma
department of onco-hematology, ibn rochd university hospital, casablanca, morocco
نشانی اینترنتی http://mejc.sums.ac.ir/index.php/mejc/article/view/435
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/181/article-181-314409.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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