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Journal of Research in Medical Sciences، جلد ۲۱، شماره ۱۱، صفحات ۰-۰
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عنوان انگلیسی Comparison of different doses of subconjunctival sunitinib with bevacizumab in the treatment of corneal neovascularization in experimental rats
چکیده انگلیسی مقاله Background: To compare the efficacy of subconjunctival administration of bevacizumab and different doses of sunitinib malate in reducing corneal neovascularization (CNV). Materials and Methods: In this experimental study, central corneal cauterization was created in the right eye of fifty male Sprague–Dawley rats. On day 1 (1 week after cauterization), rats were randomly assigned into five treatment groups. Group control ( n = 10) received subconjunctival injection of 0.02 ml of base saline solution. Group 1 ( n = 10) received 0.02 ml of bevacizumab (25 mg/ml). Group 2, 3, and 4 ( n = 10 for each group) were treated with 0.02 ml of sunitinib malate (10, 20, and 50 ?g/ml, respectively). On days 1, 7, and 14, digital photographs of the cornea were taken, and the area of CNV was measured. Results: During the 2?week follow?up, CNV area in treatment groups was less than in control group ( P < 0.05). On day 7, corneal avascular area was highest in Group 3 at 63%. On day 14, the area of CNV in Groups 2 and 3 was less than in Group 1 ( P = 0.031 and 0.011, respectively), but the difference between Groups 2 and 3 was not statistically significant ( P = 0.552). The decreased CNV area on day 14 in Group 4 was significant in comparison to bevacizumab, but it was not significant on day 7 ( P = 0.25 on day 7 and 0.002 on day 14). Conclusion: Subconjunctival sunitinib malate is more effective than bevacizumab in regressing CNV. This effect is more prominent on day 14.
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نویسندگان مقاله محمد ناصر هاشمیان | mohammad nasser hashemian


هادی z mahrjerdi | hadi z mahrjerdi


مهدی مظلومی | mehdi mazloumi


مونا s صافی زاده | mona s safizadeh


یداله شکیبا | yadollah shakiba


فیروزه رحیمی | firouzeh rahimi


محسن آفریده | mohsen afarideh


محمد علی زارع | mohamad ali zare


محمدرضا فلاح تفتی | mohammadreza fallah tafti


بهرام بحرانی sepidan | bahram bohrani sepidan


محمد علی ابطحی | mohammad ali abtahi


سید حسین ابطحی | seyed hossein abtahi


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/10610
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/218/article-218-314422.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Articles
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