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Iranian Journal of Basic Medical Sciences، جلد ۲۰، شماره ۱، صفحات ۹۹-۱۰۶
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی In vitro assesment of anti-inflammatory activities of coumarin and Indonesian cassia extract in RAW264.7 murine macrophage cell line
چکیده انگلیسی مقاله Objective(s): Inflammation is an immune response toward injuries. Although inflammation is healing response, but in some condition it will lead to chronic disease such as rheumatoid arthritis, inflammatory bowel disease, atherosclerosis, Alzheimer’s and various cancer. Indonesian cassia (Cinnamomum burmanni C. Nees & T. Ness) known to contain coumarin, is widely used for alternative medicine especially as an antiinflammator.This study was conducted to determine the anti-inflammatory properties of coumarin and Indonesian cassia extract (ICE) in LPS-induced RAW264.7 cell line. Materials and Methods: The cytotoxic assay of coumarin and ICE against RAW264.7 cells was conducted using MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium). The anti-inflammatory potential was determined using LPS-induced RAW 267.4 macrophages cells to measure inhibitory activity of both compounds on production of nitric oxide (NO), prostaglandin E2 (PGE2), and also cytokines such as interleukin-6 (IL-6), interleukin-1β (IL-1β) and TNF-α. Results: Coumarin 10 µM and ICE 10 µg/ml were nontoxic to the RAW264.7 cells. Both of coumarin and ICE were capable to reduce the PGE2, TNF-α, NO, IL-6, and IL-β level in LPS-induced RAW264.7 cells. Coumarin had higher activity to decrease PGE2 and TNF-α, whilst ICE had higher activity to inhibit NO, IL-6, and IL-β levels. Conclusion: Coumarin and ICE possess anti-inflammatory properties through inhibition of PGE2 and NO along with pro-inflammatory cytokines TNF-α, IL-6, IL-1β production.
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نویسندگان مقاله ni made dwi sandhiutami | ni made dwi sandhiutami
faculty of pharmacy, university of pancasila, jl. srenseng sawah, jagakarsa, jakarta 12640, indonesia


moordiani moordiani | moordiani moordiani
faculty of pharmacy, university of pancasila, jl. srenseng sawah, jagakarsa, jakarta 12640, indonesia


دیان ratih laksmitawati | dian ratih laksmitawati
faculty of pharmacy, university of pancasila, jl. srenseng sawah, jagakarsa, jakarta 12640, indonesia


nurul fauziah | nurul fauziah
bimolecular and biomedical research center, aretha medika utama,jl. babakan jeruk 2 no 9, bandung 40163, indonesia


maesaroh maesaroh | maesaroh maesaroh
bimolecular and biomedical research center, aretha medika utama,jl. babakan jeruk 2 no 9, bandung 40163, indonesia


wahyu widowati | wahyu widowati
medical research center faculty of medicine, maranatha christian university, jl. prof. drg. suria sumantri no 65 bandung 40164, indonesia
نشانی اینترنتی http://ijbms.mums.ac.ir/article_8102.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-314621.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Short Communication
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