این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Avicenna Journal of Phytomedicine، جلد ۱۴، شماره ۴، صفحات ۴۱۵-۴۲۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Apigenin attenuates serum concentrations of TNF-a, interleukin 1b and interleukin 6 in lipopolysaccharide-stimulated rats
چکیده انگلیسی مقاله  Objective: The use of flavonoids is increasing due to their costeffectiveness and less adverse reaction. Therefore, the effect ofapigenin on lipopolysaccharide (LPS)-induced inflammation wasinvestigated by measuring IL-1b, IL-6, and TNF-a, of serum in themale rats.Materials and Methods: Ninety male wistar rats were divided in6 groups included; control, sham, dexamethasone 15 mg/kg,intraperitoneally (i.p.), and apigenin (5, 15, and 30 mg/kg, i.p).Thirty minutes after the administration of solvent or apigenin, LPS(30 μg/kg, i.p) was injected. At time intervals of 4, 12 and 24 hrafter injection, blood samples were taken and the concentrations ofTNF-a, IL-1b and IL-6 were measured by enzyme-linkedimmunosorbent assay.Results: Compared to the control, apigenin (5 mg/kg) decreasedthe level of TNF-a, and IL-1b in a period of 24 hr (p<0.05). Theconcentration of IL-6 decreased significantly by apigenin (15mg/kg) 24 hr after injection (p<0.05). Apigenin (30 mg/kg)decreased the level of TNF-a, at all three time points (4 hr; p<0.05,12 hr; p<0.01, and 24 hr; p<0.01), and the level of IL-1b (p<0.01),24 hr and the level of IL-6 at 4 hr (p<0.05), and 24 hr (p<0.01)after LPS injection.Conclusion: Apigenin can suppress serum inflammatorycytokines, similar to dexamethasone 
کلیدواژه‌های انگلیسی مقاله Inflammation, Apigenin, Dexamethasone, Cytokines
نویسندگان مقاله | Mohammad Sofiabadi
Cellular and Molecular Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_23365.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Short communication
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات