این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Avicenna Journal of Phytomedicine، جلد ۱۴، شماره ۴، صفحات ۴۵۵-۴۶۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The cardioprotective properties of Persicaria maculosa and Citrus sinensis extracts against doxorubicin-induced cardiotoxicity in mice
چکیده انگلیسی مقاله  Objective: This study assessed the cardioprotective properties ofPersicaria maculosa (PME) and Citrus sinensis (CME) hydromethanolic extracts, besides Citrus sinensis aqueous extract(CWE) against doxorubicin (DOX)-induced cardiotoxicity.Materials and Methods: The extracts were characterized. Micewere divided into eight groups: control (saline), DOX, protected(injected with 200 mg/kg of PME, CWE or CME for 21 days,orally, and DOX), and extracts (PME, CWE or CMEadministration, orally, for 21 days). DOX was injected (5 mg/kg,ip) on days 8, 13 and 18 of the experiment. Cardiac tumor necrosisfactor-alpha (TNF-α), nuclear factor (erythroid-derived 2)-like 2(Nrf2) and carbonyl reductase 1 (CBR1) expression levels, besidessuperoxide dismutase, catalase, malondialdehyde, nitric oxide andtotal protein levels were evaluated. Serum lactate dehydrogenase,creatine phosphokinase cardiac isoenzyme, aspartate transaminase,cholesterol, triglycerides and creatinine levels, as well as thecardiac tissues were examined.Results: Comparing with the control, DOX considerably (p<0.01)up-regulated TNF-α expression, malondialdehyde, nitric oxide,cardiac enzymes, lipids and creatinine levels, while it significantly(p<0.01) down-regulated Nrf2 and CBR1. Additionally, DOXinterfered with antioxidant enzymes' activities (p<0.01).Conversely, protected groups showed a significant (p<0.01)amelioration of DOX-induced cardiotoxic effects.Conclusion: The current study provides a new understanding of P.maculosa and C. sinensis cardioprotective mechanisms. Theextracts' cardioprotective effects may be due to their antioxidantactivities, ability to maintain the redox homeostasis throughregulation of important antioxidant genes and primary antioxidantenzymes, and capability to recover inflammatory cytokines andlipids levels. Noteworthy, the tested extracts showed no toxicchanges on the normal mice. 
کلیدواژه‌های انگلیسی مقاله Antioxidants, Doxorubicin, Oxidative stress, Toxicity, Nrf2, CBR1
نویسندگان مقاله | Mohammad Zaki
Department of Chemistry, Faculty of Science, University of Kafrelsheikh, Kafr El-Sheikh, Egypt


| Ibrahim Helmi El-Sayed
Department of Chemistry, Faculty of Science, University of Kafrelsheikh, Kafr El-Sheikh, Egypt


| Mamdouh Abdel-Mogib
Department of Chemistry, Faculty of Science, University of Mansoura, Mansoura, Egypt


| Ashraf El-Shehawy
Department of Chemistry, Faculty of Science, University of Kafrelsheikh, Kafr El-Sheikh, Egypt


| Omali El-Khawaga
Department of Chemistry, Faculty of Science, University of Mansoura, Mansoura, Egypt
نشانی اینترنتی https://ajp.mums.ac.ir/article_24101.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات