| چکیده انگلیسی مقاله |
Spinal cord injury (SCI) is a complex, multifaceted, progressive, and yet incurable complication that can cause irreversible damage to the individual, family, and society. In recent years strategies for the management and rehabilitation of SCI besides axonal regeneration, remyelination, and neuronal plasticity of the injured spinal cord have significantly improved. Although most of the current research and therapeutic advances have been made in animal models, so far, no specific and complete treatment has been reported for SCI in humans. The failure to treat this complication has been due to the inherent neurological complexity and the structural, cellular, molecular, and biochemical characteristics of spinal cord injury. In this review, in addition to elucidating the causes of spinal cord injury from a molecular and pathophysiological perspective, the complexity and drawbacks of neural regeneration that lead to the failure in SCI treatment are described. Also, recent advances and cutting -edge strategies in most areas of SCI treatment are presented. Level of evidence: I |
| نویسندگان مقاله |
| Davood Yari
1 Department of Clinical Biochemistry, Babol University of
Medical Sciences, Babol, Iran
2 Orthopedic Research Center, Mashhad University of
Medical Sciences, Mashhad, Iran
| Arezoo Saberi
Department of Pharmaceutics, School of Pharmacy,
Mashhad University of Medical Sciences, Mashhad, Iran
| Zahra Salmasi
4 Nanotechnology Research Center, Pharmaceutical
Technology Institute, Mashhad University of Medical
Sciences, Mashhad, Iran
5 Department of Pharmaceutical Nanotechnology, School
of Pharmacy, Mashhad University of Medical Sciences,
Mashhad, Iran
| Seyed Alireza Ghoreishi
2 Orthopedic Research Center, Mashhad University of
Medical Sciences, Mashhad, Iran 6 Department of Orthopedic Surgery, Faculty of Medicine,
Mashhad University of Medical Sciences, Mashhad, Iran
| Leila Etemad
Department of Orthopedic Surgery, Faculty of Medicine,
Mashhad University of Medical Sciences, Mashhad, Iran
| Jebrail Movaffagh
Department of Pharmaceutics, School of Pharmacy,
Mashhad University of Medical Sciences, Mashhad, Iran- Pharmaceutical Research Center, Pharmaceutical
Technology Institute, Mashhad University of Medical
Sciences, Mashhad, Iran
| Babak Ganjeifar
Targeted Drug Delivery Research Center,
Pharmaceutical Technology Institute, Mashhad
University of Medical Sciences, Mashhad, Iran- Department of Neurosurgery, Ghaem Hospital, Mashhad
University of Medical Sciences, Mashhad, Iran
|