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Iranian Journal of Basic Medical Sciences، جلد ۲۷، شماره ۸، صفحات ۹۹۶-۱۰۰۴
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عنوان انگلیسی Effects of Olea oleaster leaf extract and purified oleuropein on ethanol-induced gastric ulcer in male Wistar rats
چکیده انگلیسی مقاله Objective(s): Evaluating the effect of fresh Oleaster leaf extract (OLE) and purified oleuropein (OLR) on ethanol-induced gastric ulcers in rats. HPLC analysis demonstrates the presence of various polyphenol compounds such as ligstroside, luteolin derivative, oleuropein, and comselogoside. Materials and Methods: Gastric ulcer was induced by administration of ethanol by the gastric gavage route. The olive leaf extract was analyzed by HPLC-PDA-ESI-MS, and OLR was purified. These two compounds were given 2 hr before gastric ulcer induction by ethanol.Results: This study verified that OLE and purified OLR protect from ethanol-induced gastric ulceration and damage, evidenced by the significant decrease in gastric ulcer urea (by 74 and 58% respectively) and stomach mucus content (by 169 and 87% respectively). In addition, the ulcer index (UI) and curative index (CI) levels in the stomach of the rats treated with this supplement were also suppressed by 55 and 46%, respectively. OLE and OLR also decreased the gastric myeloperoxidase (MPO) activity and ameliorated the Nitric oxide (NO) content. OLE and OL also ingestion suppressed gastric tumor necrosis factor-alpha (TNF-α) and interleukin (IL-6) rates. Macroscopic and histological findings revealed that OLE and OLR protect from gastric hemorrhage, severe disruption of the gastric mucosa, and neutrophil infiltration.Conclusion: Overall, the findings demonstrate that OLE and OLR have both promising potential with regard to the inhibition of gastric hemorrhage and lesions.
کلیدواژه‌های انگلیسی مقاله Inflammation, Nitric oxide, Olea oleaster, Oleuropein, Ulcer
نویسندگان مقاله | Fatiha Abdellah
Laboratory of Bioresources, Integrative Biology and Exploiting, Higher Institute of Biotechnology of Monastir, University of Monastir, Tunisia


| Tayeb Silarbi
Laboratory of Research on Local Animal Products, Ibn-Khaldoun University, Tiaret, Algeria


| Ferjeni Zouidi
Biology Department, Faculty of Sciences and Arts of Muhayil Asir, King Khaled University; Saudi Arabia


| Khaled Hamden
Laboratory of Bioresources, Integrative Biology and Exploiting, Higher Institute of Biotechnology of Monastir, University of Monastir, Tunisia
نشانی اینترنتی https://ijbms.mums.ac.ir/article_24147.html
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