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Journal of Nanostructures، جلد ۶، شماره ۴، صفحات ۲۸۵-۲۹۲
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عنوان انگلیسی Controlled Antibiotic Delivery by Gelatin Nanospheres: Optimization, Characterization and Antibacterial Evaluation
چکیده انگلیسی مقاله The present work focuses on preparation and characterization of erythromycin loaded gelatin nanoparticles through nanoprecipitation method. The procedure consists of the increase of the aqueous gelatin solution to the non-solvent phase containing Lutherol F127. Three different measures of cross-linker and polymer concentration were also examined, and the optimum concentration was found. The morphology of gelatin nanoparticles was characterized by FE-SEM. It was shown that the optimal morphology can be achieved at the concentration of 1.25 wt % of gelatin in aqueous phase by addition of 20 mL of glutaraldehyde 5%, as the crosslinking agent. Nanoparticle wet size determination was carried out using a DLS system and found to be approximately 100 nm. Furthermore, Erythromycin release studies proved the suitability of these particles as a drug delivery system, at least in the studied 72 hours interval. As suggested by related measurements, these nanoparticles are good candidates for antibacterial agent in any possible related application.
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نویسندگان مقاله شهرزاد fathollahipour |
division of biomedical engineering, faculty of new sciences and technologies, university of tehran
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

آزاده غایی |
division of biomedical engineering, faculty of new sciences and technologies, university of tehran
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

علی ابویی مهریزی | abouei mehrizi
division of biomedical engineering, faculty of new sciences and technologies, university of tehran
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

مجتبی کوشا |
department of pulp and paper, energy and new technologies engineering faculty, zirab campus, shahid beheshti university, mazandaran, iran
سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

نشانی اینترنتی http://jns.kashanu.ac.ir/article_34330_7e63179589ba4a4ef46bf07e01c3a035.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/497/article-497-315519.pdf
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زبان مقاله منتشر شده en
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