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Iranian Journal of Kidney Diseases، جلد ۱۸، شماره ۰۳، صفحات ۱۵۹-۱۶۷
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عنوان انگلیسی Shenqi Pill Mitigates Renal Interstitial Fibrosis Through Weakening Notch1/Jag1 Pathway
چکیده انگلیسی مقاله Introduction. Shenqi pill (SQP) can be used to treat various kidneyrelated diseases, but its exact mechanism of action remains unclear. We intended to analyze the role and mechanism of SQP on renal interstitial fibrosis (RIF).Methods. After performing unilateral ureteral obstruction (UUO) surgery following the Institutional Animal Care and Use Committee guidelines, all rats were assigned into the sham group, UUO group, UUO + SQP 1.5 g/kg, UUO + SQP 3 g/kg, and UUO + SQP 6 g/kg groups. After treatment with SQP for 4 weeks, the appearance of kidney, serum creatinine (SCr), and blood urea nitrogen (BUN) levels were monitored in each group. The pathological injury, extracellular matrix (ECM), and Notch1 pathway-related protein levels were measured using H&E staining, Masson staining, immunohistochemistry, and Western blot, respectively.Results. SQP could obviously ameliorate the appearance of the kidney as well as the levels of SCr and BUN in UUO rats (SCr: 67.6 ± 4.64 μM, 59.66 ± 4.96 μM, 48.76 ± 4.44 μM, 40.43 ± 3.02 μM for UUO, low, medium, and high SQP treatment groups; BUN: 9.09 ± 0.97 mM, 7.72 ± 0.61 mM, 5.42 ± 0.42 mM, 4.24 ± 0.34 mM for UUO, low, medium, and high SQP treatment groups; P < .05). SQP also effectively mitigated renal tissue injury in UUO rats (P < .05). Moreover, we uncovered that SQP significantly inhibited Collagen I, α-SMA, Collagen IV, TGF-β1, Notch1, and Jag1 protein expressions in UUO rats’ kidney (P < .05).Conclusion. Our data elucidated that SQP can alleviate RIF, and the mechanism may be related to the Notch1/Jag1 pathway. DOI: 10.52547/ijkd.7703
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نویسندگان مقاله | Hongshu Chen
The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China


| Yuanxiao Yang
School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou 310053, China


| Xiaojie Zhou
Acadamy of Chinese Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China


| Yaorong Feng
The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, China
نشانی اینترنتی https://ijkd.org/index.php/ijkd/article/view/7703
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کد مقاله (doi) 10.52547/b56av842
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده ORIGINAL | Kidney Diseases
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