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International Journal of Organ Transplantation Medicine، جلد ۸، شماره ۱، صفحات ۰-۰
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عنوان انگلیسی The Effect of Osmotherapy and Tight Control of Acidosis on Early Graft Function among Deceased- Donor Kidney Transplant Recipients: A Randomized Controlled Trial
چکیده انگلیسی مقاله Background: Reperfusion injury and the acid-base status of the transplant are important factors affecting post-transplantation graft function. Objective: We hypothesized that infusing hypertonic saline (HS) or tight control of acid-base status of the blood rushing through renal graft using sodium bicarbonate may have beneficial effects on early graft function. Methods: Candidates for deceased-donor kidney transplant were randomized into three groups. HS group (n=33) received 50 mL/kg normal saline (NS) titrated during operation plus 4 mL/kg of 5% HS just within graft reperfusion phase; bicarbonate group (n=37) was administered 60 mL/kg NS while their metabolic acidosis (base excess ≤‑5 mEq/L) was tightly corrected every 30 min with sodium bicarbonate; and a control group (n=36) that received 60 mL/kg normal saline while they were administered sodium bicarbonate only, if they encountered severe metabolic acidosis (base excess ≤‑15 mEq/L). The primary outcome was defined as early post-operative renal function evaluated based on serial serum creatinine levels. The study was registered in Iranian Registry of Clinical Trials (IRCT2013122815841N19). Results: Post-operative early graft function improved significantly during the first 3 days in the intervention groups (p< 0.05). However, that beneficial effect no longer remained at the same level after the day four. Conclusion: Timely administration of HS or tight control of metabolic acidosis with sodium bicarbonate infusion improve early renal function during renal transplant surgery.
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نویسندگان مقاله f اعتضادی | f etezadi


ah نجفی ابرندآبادی | ah najafi abrandabadi


j مطهری نیا | j motaharinia


m مجتهدزاده | m mojtahedzadeh


p پورفخر | p pourfakhr


mr خواجوی | mr khajavi


s گوران | s gooran


r شریعت محرری | r shariat moharari


s دهقانی | s dehghani


نشانی اینترنتی http://www.ijotm.com/ojs/index.php/IJOTM/article/view/333
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