این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Public Health، جلد ۵۳، شماره ۶، صفحات ۱۲۴۶-۱۲۶۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Adjunctive Drug-Loaded Gel in the Treatment of Periodontitis: A Systematic Evaluation and Meta-Analysis
چکیده انگلیسی مقاله Background: This meta-analysis aimed to systematically investigate the efficacy of drug-loaded gel adjuncts in the treatment of periodontitis. Methods: A comprehensive search was conducted in six databases, i.e., the China National Knowledge Infrastructure, WanFang Data, VIP Chinese Science and Technology Periodical Database, China Biology Medicine Disc, Cochrane Library, PubMed, and Web of Science, from the inception until Jun 2023. The search focused on randomized controlled trials that examined the application of drug-loaded gels in the treatment of periodontitis. Periodontal probing depth and clinical attachment level were the primary and secondary outcomes, respectively. Stata 15.0 and Review Manager 5.4 were employed to perform the meta-analysis using the selected articles that met the predefined criteria. Results: This study included 16 randomized controlled trials involving 1146 participants. Subgroup analyses based on the follow-up period revealed that the gel-based drug-assisted subgingival root planning intervention had more favorable effects on periodontal probing depth (standardized mean difference=0.50, 95% confidence interval=[0.32, 0.68], I2=56.0%, P=0.001) and clinical attachment level (standardized mean difference=0.47, 95% confidence interval=[0.29, 0.66], I2=57.0%, P=0.0007) than the subgingival root planning intervention alone. However, subgroup analysis based on the action mechanism of gel drugs showed no statistically significant differences in periodontal probing depth and clinical attachment level between groups. Conclusion: The application of the drug-loaded gel as adjunctive therapy for periodontitis effectively reduced periodontal probing depth and promoted clinical attachment level recovery. The findings provide evidence-based support for the efficacy, security, and rational use of drug-loaded gel in the treatment of periodontitis.  
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Zhige Li
1. School (Hospital) of Stomatology, Lanzhou University, Lanzhou, 730000, China 2. Gansu Province Key Lab of Maxillofacial Reconstruction and Intelligent Manufacturing, Lanzhou 730000, China


| Xin Yang
School (Hospital) of Stomatology, Lanzhou University, Lanzhou, 730000, China


| Jiao Wang
School (Hospital) of Stomatology, Lanzhou University, Lanzhou, 730000, China


| Ziyang Qin
School (Hospital) of Stomatology, Lanzhou University, Lanzhou, 730000, China


| Yucheng Meng
School (Hospital) of Stomatology, Lanzhou University, Lanzhou, 730000, China


| Baoping Zhang
1. School (Hospital) of Stomatology, Lanzhou University, Lanzhou, 730000, China 2. Gansu Province Key Lab of Maxillofacial Reconstruction and Intelligent Manufacturing, Lanzhou 730000, China 3. Institute of Biomechanics and Medical Engineering, Lanzhou University, Lanzhou, 730000, China 4. Key Laboratory of Mechanics on Disaster and Environment in Western China, Ministry of Education, Lanzhou University, Lanzhou, 730000, China
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/30690
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات