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Research Journal of Pharmacognosy، جلد ۱۱، شماره ۳، صفحات ۵۳-۶۵
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عنوان انگلیسی Mitigation of Ochratoxin A-Induced Renal Toxicity by Kaempferol in Albino Mice
چکیده انگلیسی مقاله Background and objective: This study investigated the protective effects of kaempferol, a natural flavonoid known for its antioxidant properties, against ochratoxin A-induced renal damage. Ochratoxin A, a nephrotoxic mycotoxin found in contaminated food and feed, primarily induces renal damage through oxidative stress. The objective was to assess kaempferol’s potential in mitigating ochratoxin A -induced renal toxicity and its underlying molecular mechanisms. Methods: Male albino mice were divided into four groups: normal control, kaempferol control, ochratoxin A -induced renal toxicity, and ochratoxin A -induced renal toxicity treated with kaempferol. Ochratoxin A was administered twice a week for 8 weeks at 5 mg/kg body weight to induce renal toxicity. Kaempferol (50 mg/kg) was administered twice a week for 8 weeks after a 4-hour interval following ochratoxin A administration. Results: Results showed that kaempferol normalized levels of blood urea nitrogen (BUN) and creatinine, indicating protection against ochratoxin A-induced pathophysiology. Kaempferol also increased phosphorylation of PI3K and AKT, potentially activating antioxidative and anti-apoptotic signaling pathways regulated by Nrf2. Additionally, kaempferol enhanced Bcl-2 activation while suppressing caspase-3, suggesting anti-apoptotic effects. Histopathological analysis revealed reduced renal damage in kaempferol-treated mice compared to those exposed to ochratoxin A alone. Conclusion: Kaempferol demonstrated efficacy in preventing ochratoxin A -induced kidney injury through antioxidative and anti-apoptotic mechanisms. These findings suggest potential therapeutic applications of kaempferol in oxidative stress-induced renal damage.
 
کلیدواژه‌های انگلیسی مقاله kaempferol,ochratoxin A,oxidative stress,PI3K/Akt,renal toxicity
نویسندگان مقاله Norah Fahad Saad Bosaad |
Department of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, Saudi Arabia.

Peramaiyan Rajendran |
Department of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, Saudi Arabia.

Rebai Ben Ammar |
Department of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, Saudi Arabia.

Gamal Mahmoud Bekhet |
Department of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, Saudi Arabia.

Mohammed Salem Moqbel |
Department of Anatomy, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.

Saeed Yaseen Al-Ramadan |
Department of Anatomy, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.

Hamad Abu Zahra |
Department of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, Saudi Arabia.

نشانی اینترنتی https://www.rjpharmacognosy.ir/article_196185_aca7171128cc18f7537565220432ffb8.pdf
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