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Journal of Pharmaceutical Care، جلد ۱۲، شماره ۲، صفحات ۱۱۹-۱۳۰
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عنوان انگلیسی 5-Lipoxygenase: The Therapeutically Unexplored Target for Bone Health
چکیده انگلیسی مقاله Bone fracture is a common orthopedic condition that represents a significant health concern. Bone fracture repair process is a complex process that involves the harmonic and synchronized activity of bone cells. 5-lipoxygenase (5-LOX) is an enzyme responsible for the conversion of arachidonic acid to form leukotrienes. While leukotrienes have an empirical inflammatory role, various evidence suggests that these 5-LOX mediators, by switching the inflammatory environment and altering the activity of bone cells, have a detrimental effect on the bone fracture healing process. Additionally, various evidence suggests that 5-LOX inhibition shows improvement in the overall bone healing process and improves overall bone health. Despite this evidence, the clinical use of 5-LOX inhibitors in bone fracture healing is largely unexplored. The current review aimed to summarize the available evidence and pave the way for future large scale pre-clinical and clinical studies to evaluate the effectiveness of selective 5-LOX inhibitors in bone fracture healing.
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نویسندگان مقاله | Jignesh Kansagra
Department of Scientific and Medical Affairs, Sundyota Numandis Probioceuticals Pvt. Ltd., Gujarat, India


| Vishal Dubey
Department of Scientific and Medical Affairs, Sundyota Numandis Probioceuticals Pvt. Ltd., Gujarat, India


| Dharmeshkumar Kheni
Department of Scientific and Medical Affairs, Sundyota Numandis Probioceuticals Pvt. Ltd., Gujarat, India


| Varun Sureja
Department of Scientific and Medical Affairs, Sundyota Numandis Probioceuticals Pvt. Ltd., Gujarat, India
نشانی اینترنتی https://jpc.tums.ac.ir/index.php/jpc/article/view/653
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