این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Chemistry and Chemical Engineering، جلد ۴۲، شماره ۱۲، صفحات ۴۰۰۰-۴۰۱۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Anti-Colon Cancer, Anti-HMG-CoA Reductase, Anti-Urease Activities, and Molecular Docking Studies of Some Natural Compounds
چکیده انگلیسی مقاله The creation of novel enzyme inhibitors and anti-cancer therapeutics has recently been one of medicinal chemistry's main objectives. Furthermore, the β-Hydroxy β-methylglutaryl-CoA (HMG-CoA) reductase and urease enzyme inhibition activities of these compounds were investigated. The obtained results revealed that Bavachalcone, with IC50 value of 13.27±1.38 µM against HMG-CoA reductase, and Ladanein with IC50 value of 3.08±0.25 µM against urease, were the most potent compounds against both assigned enzymes. It should be emphasized that all substances were more effective at inhibiting both enzymes than the common inhibitor tacrine. The chemical activities of bavachalcone, isobavachalcone, ladanein, and salvigenin against pancreatic HMG-COA reductase and urease were evaluated by conducting a molecular docking study. The anti-cancer activities of these compounds were investigated against colon cancer cells such as SNU-C1, SW48, RKO, COLO-205, SW1417, and LS411N. The chemical activities of bavachalcone, isobavachalcone, ladanein, and salvigenin against some of the expressed surface receptor proteins (CD44, endothelin receptor, EGFR, CD47, CXCR4, and HER2) in the mentioned cell lines were assessed using the molecular docking calculations. In the cancer part, all of the investigated molecules, exhibited the most potent growth inhibition in the six colon cancer cells, with an IC50 value of 5.56–200 µM, indicating that they are more powerful than 5FU, which exhibited an IC50 value of 37.36±4.69–56.06±6.82 µM except for Ladanein. The docking scores showed that these compounds have strong binding affinities to the enzymes and receptors. In addition, the compounds formed strong contacts with the proteins. Thus, these compounds could be potential inhibitors for enzymes and cancer cells.
کلیدواژه‌های انگلیسی مقاله natural compounds,HMG-COA reductase,Urease,Colon cancer,Molecular modeling
نویسندگان مقاله Rui Zhang |
Department of Burn Plastic Surgery, Central Hospital Affiliated to Shandong First Medical University, No. 105 Jiefang Road, Jinan, Shandong Province, 250013, P.R. CHINA

Yuchao Wen |
Department of Burn Plastic Surgery, Central Hospital Affiliated to Shandong First Medical University, No. 105 Jiefang Road, Jinan, Shandong Province, 250013, P.R. CHINA

Ning Yan |
Department of Plastic Surgery, Central Hospital Affiliated to Shandong First Medical University, No. 105 Jiefang Road, Jinan, Shandong Province, 250013, P.R. CHINA

Jianying Zhang |
Department of Anorectal, Central Hospital Affiliated to Shandong First Medical University, No. 105 Jiefang Road, Jinan, Shandong Province, 250013, P.R. CHINA

نشانی اینترنتی https://ijcce.ac.ir/article_706088_4d73bc4560f8a43ea361c1a1bc26626d.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات