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International Journal of Radiation Research، جلد ۲۲، شماره ۳، صفحات ۵۲۳-۵۳۰
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عنوان انگلیسی Rat brain and testicular tissue effects of radiofrequency radiation exposure: Histopathological, DNA damage of brain and qRT-PCR analysis
چکیده انگلیسی مقاله
Background: The Background: We evaluate the effects of radiofrequency electromagnetic field (RF-EMF) on rat brain and testicular tissue using histopathology, comet assay, and real-time quantitative PCR techniques. Materials and Methods: Two equal groups of fourteen rats one for sham-control and the other for exposure (n = seven) were created. For a duration of 14 days, the exposure group (2100 MHz, testicular tissue SAR values of 163 mW/kg for 10 g, brain tissue SAR values of 292 mW/kg on average) was subjected to five hours of exposure per day. Evaluations were conducted on tissue gene expression levels, histopathology, and DNA damage to brain tissue. Results: The histological examination of brain tissue from the exposed group revealed vascular alterations and significant edema (p < 0.05). It was determined that RF radiation-induced much more cellular damage in the exposed group (18.26% tail DNA) than in the control group (4.06% tail DNA). Signs of deterioration in spermatogenic cells in the testicular tissue of the exposed group also changed significantly (p < 0.05). The Bax and bcl-2 genes showed a significant difference (p < 0.05) in the mRNA level data, whereas the p53 genes showed no significant change (p > 0.05). Conclusion: These findings suggest that it may cause some histopathological and cellular damage in brain and testis tissue.
کلیدواژه‌های انگلیسی مقاله 2100 MHz, Brain, Radiation, Histopathological, qRT-PCR, Radiofrequency, Testicular.
نویسندگان مقاله | M.C. Yavas
Department of Biophysics, Faculty of Medicine, Mardin Artuklu University, Mardin, Turkey


| A. Kilitci
Department of Pathology, Faculty of Medicine, Düzce University, Düzce, Turkey


| E. Çelik
Department of Medical Biology, Faculty of Medicine, Kırşehir Ahi Evran University, Kırşehir, Turkey


| K. Yegin
Department of Electrical and Electronics Engineering, Ege University, Izmir, Turkey


| B. Sirav
Department of Biophysics, Faculty of Medicine, Gazi University, Ankara, Turkey


| S. Varol
Department of Biophysics, Faculty of Medicine, Erciyes University, Kayseri, Turkey
نشانی اینترنتی http://ijrr.com/browse.php?a_code=A-10-1-1205&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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