| چکیده انگلیسی مقاله |
Interest in naturally occurring phytochemicals has been on the increase, they are believed to reduce the risk of brain disorders. Hispidulin (HN) is a phenolic flavonoid compound with various pharmacological and biological effects on the central nervous system. It belongs to the flavone class of flavonoids. It can be found in different plant materials, especially fruits and vegetables. The literature used in this review was collected from credible scientific databases including ScienceDirect, Scopus, PubMed, Google Scholar, and Hindawi without time restriction, using relevant keywords, such as HN, brain, central nervous system, flavonoids, and flavones. HN was discovered to possess pro-apoptotic properties, act as an antioxidant, inhibit cytokine production and toll-like receptor 4 expression, as well as impede nuclear factor kappa beta and mitogen-activated protein kinase B. HN was also found to inhibit lipid peroxidation in vitro and reduce brain edema in mice. These pharmacological potentials suggest that HN is a promising candidate for neuroprotection in CNS disorders like depression and epilepsy. This review provides an update on the scientific literature concerning how these activities could help provide various forms of neuroprotection in the CNS. Additional experimental data on the effects of HN in models of neurological disorders and neuroprotection should be explored further. Based on the current study, HN is a promising candidate for neuroprotection of the CNS. |
| نویسندگان مقاله |
| Mustapha Saeed
Department of Human Physiology, Faculty of Basic Medical Sciences, Federal University Dutse, PMB 7156, Jigawa State, Nigeria|Department of Human Physiology, Faculty of Basic Medical Sciences, Ahmadu Bello University (ABU), 810107, Zaria, Nigeria
| Rabiu Magaji
Department of Human Physiology, Faculty of Basic Medical Sciences, Ahmadu Bello University (ABU), 810107, Zaria, Nigeria
| Mohammed Magaji
Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Ahmadu Bello University (ABU), 810107, Zaria, Nigeria
| Ibrahim Gaya
Department of Human Physiology, Faculty of Basic Medical Sciences, Ahmadu Bello University (ABU), 810107, Zaria, Nigeria
| Baraka Umar
Department of Human Physiology, Faculty of Basic Medical Sciences, Ahmadu Bello University (ABU), 810107, Zaria, Nigeria
| Yusuf Yusha'u
Department of Human Physiology, Faculty of Basic Medical Sciences, Ahmadu Bello University (ABU), 810107, Zaria, Nigeria
| Abubakar Daku
Department of Human Physiology, Faculty of Basic Medical Sciences, Federal University Dutse, PMB 7156, Jigawa State, Nigeria|School of Health Sciences, Universiti Sains Malaysia, Kuban Kerian, Kelantan, Malaysia
| Musa Chiroma
Neucastle University Medicine Malaysia (NuMed), No. 1, Jalan Serjana 1, Kota ilmu, 79200 Iskandar Puteri (formerly Nusajaya) Johor-Malaysia
| Aliyu Jaafar
Department of Human Anatomy, Faculty of Basic Medical Sciences, Ahmadu Bello University (ABU), 810107, Zaria, Nigeria
| Mohamad Mehat
Department of Anatomy, Faculty of Medicine and Health Science, University Putra Malaysia (UPM), Serdang 43400, Selangor, Malaysia
| Che Norma Mat Taib
Department of Anatomy, Faculty of Medicine and Health Science, University Putra Malaysia (UPM), Serdang 43400, Selangor, Malaysia
| Mohamad Aris Mohd Moklas
Department of Anatomy, Faculty of Medicine and Health Science, University Putra Malaysia (UPM), Serdang 43400, Selangor, Malaysia
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