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Iranian Journal of Basic Medical Sciences، جلد ۲۷، شماره ۹، صفحات ۱۱۱۵-۱۱۲۳
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عنوان انگلیسی Effect of prenatal exposure to stress and extremely low-frequency electromagnetic field on hippocampal and serum BDNF levels in male adult rat offspring
چکیده انگلیسی مقاله Objective(s): Prenatal stress (PS) can adversely affect cognitive and psychological functions in the offspring. This study aimed to determine the effect of PS and extremely low-frequency electromagnetic field (ELF-EMF) on spatial memory, serum corticosterone, brain-derived neurotrophic factor (BDNF) concentrations, and hippocampal BDNF levels in adult male offspring. Materials and Methods: Female Wistar rats were randomly divided into four groups (n=6): Control, Stress, ELF-EMF (exposure to ELF-EMF), and S+EMF (simultaneous exposure to stress and the ELF-EMF) groups. Animals received interven-tions for 21 days before and 21 days during pregnancy (a total of 42 days). On the offspring’s 90th postnatal day (PND), spatial memory was tested using Morris Water Maze, serum Corticosterone and BDNF levels were measured by the ELISA method, and hippocampal BDNF levels were measured by Western blotting. Results: PS did not affect spatial memory in the adult male offspring; however, it significantly (P<0.05) increased se-rum corticosterone levels compared to the control and EMF groups. Simultaneous induction of stress with ELF-EMF disrupted the memory acquisition phase. Serum and hippocampal BDNF levels increased signifi-cantly (P<0.05) in the EMF group compared to the stress group. Conclusion: Based on our findings, PS can increase serum corticosterone levels without affecting spatial memory. Howev-er, induction of ELF-EMF with stress has a destructive effect on spatial memory with no change in the corti-costerone levels. Compared to stress, prenatal exposure to ELF-EMF increases serum and hippocampal BDNF levels. Further studies are needed to determine the underlying mechanisms of these findings.
کلیدواژه‌های انگلیسی مقاله BDNF, Corticosterone, ELF-EMF, Prenatal stress, Spatial Memory
نویسندگان مقاله | Hajar Abkhezr
Tabriz University of Medical Sciences, Tabriz, Iran


| Shirin Babri
Tabriz University of Medical Sciences, Tabriz, Iran


| Mahsa Farid Habibi
Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Fereshteh Farajdokht
Tabriz University of Medical Sciences, Tabriz, Iran


| Saeed Sadig-Etegad
Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Gisou Mohaddes
Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran|Department of Biomedical Education, California Health Sciences Universi-ty, College of Osteopathic Medicine, Clovis, CA, USA
نشانی اینترنتی https://ijbms.mums.ac.ir/article_24288.html
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