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Iranian Journal of Basic Medical Sciences، جلد ۲۷، شماره ۹، صفحات ۱۱۸۰-۱۱۸۶
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عنوان انگلیسی Effects of dose-dependent chronic caffeine consumption in a rat burn wound model: Histopathological and immunohistochemical evaluation
چکیده انگلیسی مقاله Objective(s): Using histopathological and immunohistochemical methods, we aimed to examine the dose-dependent effects of chronic caffeine consumption on the recovery of burn wounds in an in vivo rat model.Materials and Methods: Forty-five rats were randomly assigned to a high-dose group (20 mg/kg per day for eight weeks; n=15), a low-dose group (10 mg/kg per day for eight weeks; n=15), or a control group (n=15). The burn model was created in rats. The groups were separated into three subgroups (n=5) based on the day after injury (7th, 14th, or 21st day). The wound area, wound closure percentage, and histopathological and immunohistochemical reactivity were evaluated.Results: Successful wound healing was noted in rats treated with low doses of caffeine, similar to the control group. Pathology revealed low re-epithelization, low inflammation, and high granulation in the high-dose group. In addition, there was a significant difference between the control and high-dose groups regarding the immunohistochemical reactivity of αVβ3 integrin, VEGF, and MMP-9 (P<0.05).Conclusion: We demonstrated that chronic caffeine consumption in rats adversely affects the recovery process of wounds in a dose-dependent manner. This effect may occur through delayed wound healing via the molecules MMP-9, αVβ3 integrin, and VEGF. Treatment that modulates these molecules can lead to enhanced and quicker recovery of damaged skin in coffee lovers.
کلیدواژه‌های انگلیسی مقاله Caffeine, Integrin, MMP-9, VEGF, Wound healing
نویسندگان مقاله | Filiz Yılmaz
Hitit University, Training and Research Hospital, IVF Center, Corum, Turkey


| Selma Aydemir
Dokuz Eylul University, Faculty of Medicine, Department of Histology and Embryology, Izmir, Turkey


| Bayram Yilmaz
Hitit University, Training and Research Hospital, Pathology Department, Corum, Turkey


| Orkun Ilgen
Dokuz Eylul University, Faculty of Medicine, Department of Obstetrics and Gynecology, Izmir, Turkey


| Sefa Kurt
Dokuz Eylul University, Faculty of Medicine, Department of Obstetrics and Gynecology, Izmir, Turkey


| Basak Baykara
Dokuz Eylul University, Faculty of Medicine, Department of Histology and Embryology, Izmir, Turkey
نشانی اینترنتی https://ijbms.mums.ac.ir/article_24406.html
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