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Research in Pharmaceutical Sciences، جلد ۱۹، شماره ۳، صفحات ۲۶۷-۲۷۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Spiroconjugated 1,2,3-triazolo[5,1-b]1,3,4-thiadiazine stimulates functional activity of fibroblasts under skin injury regeneration
چکیده انگلیسی مقاله Background and purpose: One of the most important mechanisms of tissue regeneration is the high functional activity of cells, including proliferation. Currently, there are practically no effective skin cell activators on the pharmaceutical market. The purpose of this work was to demonstrate the stimulating effect of spiroconjugated 1,2,3-triazolo[5,1- b ]1,3,4-thiadiazine (STT) on the functional activity of fibroblasts. Experimental approach: STT containing ointment for dermal application was made. To assess in vivo effect of the STT a linear wound model in rats was tested. A combination of histological techniques and mechanical testing was employed to estimate the stimulating effect of STT on the functional activity of fibroblasts. Findings/Results: The STT significantly increased the number of fibroblasts as well as the density and order of produced collagen fibers in the dermis during the wound healing process. As a result, a tissue was formed at the site of damage with the structure corresponding to normal skin. In addition, skin functions were restored, in particular mechanically. Conclusion and implications: The results suggested the stimulating effect of the STT on fibroblast activity and demonstrated its potential for skin regeneration.    
کلیدواژه‌های انگلیسی مقاله Collagen,Fibroblasts, Ki-67,Mast cells,Skin wound,1,2,3-Triazolo-1,3,4-thiadiazine,Vimentin.
نویسندگان مقاله | Irina M Petrova
Ural Federal University named after the first President of Russia B. N. Yeltsin, Yekaterinburg, 620026, Russia


| Sofya Iu Chebanova
Ural Federal University named after the first President of Russia B. N. Yeltsin, Yekaterinburg, 620026, Russia Federal State Budgetary Scientific Institution “Ural Federal Agrarian Scientific Research Centre, Ural Branch of Russian Academy of Sciences”, Yekaterinburg, 620142, Russia.


| Sergey L Khatsko
Ural Federal University named after the first President of Russia B. N. Yeltsin, Yekaterinburg, 620026, Russia


| Tatyana A Kalinina
Ural Federal University named after the first President of Russia B. N. Yeltsin, Yekaterinburg, 620026, Russia Ural State Mining University, Yekaterinburg, 620144, Russia.


| Dmitry V Zaitsev
Ural Federal University named after the first President of Russia B. N. Yeltsin, Yekaterinburg, 620026, Russia


| Tatyana V Glukhareva


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2248
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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