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Research in Pharmaceutical Sciences، جلد ۱۹، شماره ۳، صفحات ۲۸۷-۳۰۲
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چکیده فارسی مقاله
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عنوان انگلیسی A bioinformatics approach of specificity protein transcription factors in head and neck squamous cell carcinoma
چکیده انگلیسی مقاله Background and purpose: The seventh most common type of cancer with increasing diagnosis rates around the world is head and neck squamous cell carcinoma (HNSCC). Specificity proteins (SPs) have been known for their role in the regulation of cellular division, growth, and apoptotic pathways in various cancers. In this work, we analyzed the expression levels of SPs in HNSCC to assess their diagnostic and prognostic biomarker potential. Experimental approach: Differential gene expression and correlation analysis methods were used to determine the top dysregulated genes in HNSCC. Functional enrichment and protein-protein interaction analyses were done with the DAVID database and Cytoscape software to understand their function and biological processes. Receiver operating test, logistic regression, and Cox regression analyses were performed to check SP genes’ diagnostic and prognostic potential. Findings/Results: SP1 (LogFC = -0.27, P = 0.0013) and SP2 (LogFC = -0.20, P = 0.0019) genes were upregulated in HNSCC samples, while SP8 (LogFC = 2.57, P < 0.001) and SP9 (LogFC = 2.57, P < 0.001) genes were downregulated in cancer samples. A moderate positive correlation was observed among the expression levels of SP1, SP2, and SP3 genes. The SP8 and SP9 genes with AUC values of 0.79 and 0.75 demonstrated diagnostic potential which increased to 0.84 when both genes were assessed by logistic regression test. Also, the SP1 gene held a marginally significant prognostic potential. Conclusion and implications: Our findings clarify the potential of SP transcription factors as candidate diagnostic and prognostic biomarkers for early screening and treatment of HNSCC.
کلیدواژه‌های انگلیسی مقاله Head and neck squamous cell carcinoma,Specificity protein,SP1,TCGA.
نویسندگان مقاله | Adel Rezvani Sichani
Department of Biochemistry, Islamic Azad University, Falavarjan Branch, I.R. Iran.


| Ziba Rezvani Sichani
Bioscience Department, Faculty of Science and Technology (FCT), Universitat de Vic—Universitat Central de Catalunya (Uvic-UCC), 08500 Vic, Spain.


| Behnaz Yazdani
Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Mehdi Azizmohammad Looha
Bioinformatics Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Hajar Sirous


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2250
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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