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Iranian Journal of Chemistry and Chemical Engineering، جلد ۴۳، شماره ۱، صفحات ۳۳۵-۳۵۱
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عنوان انگلیسی New Thermodynamic Models to Correlate Solubility of Drugs in Supercritical Carbon Dioxide
چکیده انگلیسی مقاله Experimental measurement and modeling of the solubility of drugs in supercritical carbon dioxide have gained significant attention in the recent past. It is well known that the task of measuring solubility at desired conditions is a mammoth task; hence, modeling is essential. Further solubility is precisely needed in the process of micronizing drug particles with supercritical carbon dioxide (SC-CO2). In order to achieve this, a proper model is required, which will be utilized in predicting the solubility data at desirable experimental conditions. This work focused on the development of new solubility models based on solid-liquid equilibrium criteria. For validation, we have used existing solubility data for several drugs that fall under the antilipemic, NSAID, antibiotic, and anti-cancer groups. The proposed models were compared to three existing density models to determine their efficacy, further, the thermodynamic quantities such as total enthalpy of reaction, vaporization, and solvation of the compounds were calculated from existing models. Finally, we have reported a statistical comparison of the models considered in this study.
کلیدواژه‌های انگلیسی مقاله Akaike’s Information Criterion (AIC),New models,Pharmaceutical drugs,Solubility,Supercritical carbon dioxide
نویسندگان مقاله Sahul Hameed |
Department of Chemical Engineering, Puducherry Technological University (Formerly Known as Pondicherry Engineering College), Puducherry, INDIA

Ratna Surya Alwi |
Research Center for Computing, National Research and Innovation Agency (BRIN), Jl. Raya Jakarta-Bogor KM 46 Cibinong, INDONESIA

Chandrasekhar Garlapati |
Department of Chemical Engineering, Puducherry Technological University (Formerly Known as Pondicherry Engineering College), Puducherry, INDIA

Lika Atman Satya |
National Research and Innovation Agency (BRIN), INDONESIA

نشانی اینترنتی https://ijcce.ac.ir/article_707555_324aab5feebe3a865638fd4b9491fc97.pdf
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