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Iranian Journal of Blood and Cancer، جلد ۱۶، شماره ۲، صفحات ۱۵-۲۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluating Adverse Events in COVID-19 Recovered Convalescent Plasma Donors: A Comprehensive Analysis
چکیده انگلیسی مقاله
Background: The emergence of the COVID-19 pandemic prompted the exploration of convalescent plasma therapy (CPT) as a potential treatment modality. This study provides a comprehensive understanding of adverse events in COVID-19-recovered convalescent plasma (CP) donors for optimizing donor safety and refining donation protocols. The aim is to quantify the type and severity of adverse events associated with CP donation.
Materials and Methods: The present one-year retrospective study was undertaken in the blood center of a tertiary care hospital of Western Uttar Pradesh that was a multicentric site in the ICMR Placid trial and a dedicated COVID hospital during the first and second wave in India. Data was analyzed from donor adverse events (DARs) captured during the study period and evaluated for different parameters namely age, gender, body weight, donor status (first-time donor or previous donor), body mass index, blood volume processed, plasma volume collected and lag time between negative RT-PCR report and plasmapheresis. To determine the significance of variations in rates of DARs, Chi-square test was performed (p-value <0.05 considered significant).
Results: A total of 769 donations were performed in the study duration. The maximum donors were between the age group of 26-33 years with 301 donations were from this age group.  Out of 769 donations, 648 donors (84.3%) showed no DARs, while 121 donors (15.7%) experienced adverse reactions.
Conclusion: Our findings provide essential insights into donor safety, hoping to support and plan future pandemic response strategies against novel infectious diseases.
کلیدواژه‌های انگلیسی مقاله Plasmapheresis, Novel infections, Donor safety, Adverse reactions.
نویسندگان مقاله | Shalini Bahadur
Department of Pathology, Government Institute of Medical Sciences, Greater Noida


| Bhumika Gupta
Department of Pathology, Government Institute of Medical Sciences, Greater Noida


| Shalini Shukla
Department of Pathology, Government Institute of Medical Sciences, Greater Noida


| Paridhi -
Department of Pathology, Government Institute of Medical Sciences, Greater Noida


| Shivani Kalhan
Department of Pathology, Government Institute of Medical Sciences, Greater Noida


| Madhuvan Gupta
Department of Pathology, Government Institute of Medical Sciences, Greater Noida
نشانی اینترنتی http://ijbc.ir/browse.php?a_code=A-10-1121-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Adults Hematology & Oncology
نوع مقاله منتشر شده پژوهشی
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