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Iranian Journal of Blood and Cancer، جلد ۱۶، شماره ۲، صفحات ۸۴-۱۰۱
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چکیده فارسی مقاله
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عنوان انگلیسی Investigating the Dynamic Interplay Between Cellular Immunity and Tumor Cells in the Fight Against Cancer: An Updated Comprehensive Review
چکیده انگلیسی مقاله
The dynamic interplay between cellular immunity and tumor cells is essential in cancer advancement and response to therapy. This updated, comprehensive review examines the intricate relationship between these components, focusing on the function of different subsets of immune cells in both innate and acquired immunity. A literature search was conducted to identify cytokines involved in tumor cell induction, using keywords such as cytokines, tumor cells, immune cells, and cancer. Relevant articles published between 2003 and 2024 were reviewed, and their data were summarized. The review highlights the different roles of immune cell subsets in coordinating immune responses against tumors. Tumor-associated macrophages (TAMs) And Myeloid-derived suppressor cells (MDSCs) often stimulate cancer growth and evasion of the immune system by suppressing effector cells. Eosinophils and natural killer (NK) cells contribute to tumor surveillance and cytotoxicity, while dendritic cells (DCs) recreate paramount function in T-cell activation and antigen presentation. The complement system and neutrophils contribute to immune regulation and tumor-associated inflammation. T lymphocytes, particularly antigen-presenting cells (APCs) and cytotoxic CD8+ T cells are central to acquired immunity and the anti-tumor immune response. This review highlights how cytokines interact with tumor cells and their role in cancer biology, paving the way for identifying improved prognostic and diagnostic factors. The compiled findings discuss valuable cytokines for a more effective diagnosis of tumors and an accurate prognosis prediction.
کلیدواژه‌های انگلیسی مقاله Cytokines, Tumor Cells, Cancer, Immunity Cells
نویسندگان مقاله | Seyed Ali Aghapour
Neonatal & Children᾿s Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran.


| Mehdi Torabizadeh
Abuzar Children’s Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Seyed Sobhan Bahreiny
Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Najmaldin Saki
Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.


| Mohammad Ali Jalali Far
Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.


| Arshid Yousefi-Avarvand
Department of Laboratory Sciences, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Kiana Dost Mohammad Ghasemi
Department of Medical Sciences, Lahijan Azad University of Medical Sciences, Lahijan, Gilan, Iran


| Mojtaba Aghaei
Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.


| Mohammad Mehdi Abolhasani
Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Mohammad Sharif Sharifani
School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Ehsan Sarbazjoda
Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Moslem Javidan
Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
نشانی اینترنتی http://ijbc.ir/browse.php?a_code=A-10-1105-3&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Immunology
نوع مقاله منتشر شده مقاله مروری
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