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Addiction and Health، جلد ۸، شماره ۱، صفحات ۹-۱۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Impact of Opium Addiction on Levels of Pro- and Anti-inflammatory Cytokines after ‎Surgery
چکیده انگلیسی مقاله Background : Opium addiction alters immune responses to stresses such as an injury due to changing the secretion of cytokines. The present study assessed the effect of opium addiction on the cytokines [tumor necrosis factor α (TNFα), interferon-γ (IFN-γ), interleukin-4 (IL-4), and IL-10] before and after laparotomy. Methods: Male rats were randomly divided into control and opium addicted (n = 20). Then, cytokines were measured before surgery, immediately after surgery (within 30-60 minutes) and 24 hours after surgery. Findings: IFN-γ was raised in an addicted group in three phases of the study as compared to that of the control group. IL-4 in opium addicted group decreased in two phases after surgery compared to the control group. IL-4 was lower after surgery in comparison to before surgery in the opium addicted group. The difference in IL-10 and TNFα levels was not statistically significant in the all groups measured in three phases of the investigation. Conclusion: The results revealed that opium addiction can increase plasma level of IFN-γ in rats and decrease plasma level of IL-4 after surgical stress. It seems that opium addicted rats are a more susceptible to increased inflammation.
کلیدواژه‌های انگلیسی مقاله Cytokines, Interleukins, Opium addiction, Laparotomy, Rat‎
نویسندگان مقاله محمد رضا لشکری زاده | mohammad reza lashkarizadeh
‎associate professor, department of surgery, school of medicine and afzalipour hospital, kerman ‎university of medical sciences, kerman, iran


محمد گرشاسبی | mohammad garshasbi
‎surgeon, department of surgery, school of medicine and afzalipour hospital, kerman university of ‎medical sciences, kerman, iran


محمد شعبانی | moahmmad shabani
‎associate professor, neuroscience research center, institute of neuropharmacology, kerman ‎university of medical sciences, kerman, iran


شهریار دبیری | shahriar dabiri
‎professor, department of pathology, school ‎of medicine, kerman university of medical sciences, ‎kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

هادی هادوی | hadi hadavi
‎surgeon, department of surgery, school of medicine and afzalipour hospital, kerman university of ‎medical sciences, kerman, iran


حسن منافی اناری | hasan manafi anari
assistant professor, ‎department of pathology, school of medicine, kerman university of medical sciences, ‎kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

نشانی اینترنتی http://ahj.kmu.ac.ir/ahj/index.php/ahj/article/view/327
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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