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Addiction and Health، جلد ۷، شماره ۱-۲، صفحات ۴۷-۵۳
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عنوان انگلیسی Effects of Different Concentrations of Opium on the Secretion of ‎Interleukin-6, Interferon-γ and Transforming Growth Factor Beta Cytokines ‎from Jurkat Cells
چکیده انگلیسی مقاله B ackground: The risk of infectious, autoimmune and immunodeficiency diseases and cancers rise in opioid addicts due to changes in innate and acquired immune responses. Three types of opioid receptors (К ، δ ، μ) are expressed on the surface of lymphocytes and mononuclear phagocytes. The present study was designed to examine the effects of different concentrations of opium on the secretion of some cytokines produced by lymphocyte cells. Methods: Jurkat cells were exposed to different concentrations of opium for periods of 6, 24 and 72 h in cell culture medium. The amount of interleukin-6 (IL-6), interferon-γ (IFN-γ) and transforming growth factor-b (TGF-β) were then measured using enzyme-linked immunosorbent assay (ELISA) method. Findings: The results showed that opium increases the secretion of IL-6 in different concentration of opium in 6 h. The amount of IFN-γ decreased in 6 h and increased in 24 h significantly compared with control. On the other hand, opium had an inhibitory effect on the TGF-β secretion in 6, 24 and 72 h. Conclusion: Overall, the study showed that opium stimulates pro-inflammatory and suppressed anti-inflammatory cytokine secretion in Jurkat cells. This may account for the negative effect of opium on the immune system leading to chronic inflammation and a base for many disorders in opium addicts.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله غلامرضا اسدی کرم | gholamreza asadikaram
professor, physiology research center, institute of neuropharmacology, department of biochemistry, school of medicine, kerman ‎university of medical sciences, kerman, iran


سمیه ایگدر | somayeh igder
phd student, molecular biology research center, rafsanjan university of medical sciences, rafsanjan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

زهرا جمالی | zahra jamali
phd student, molecular biology research center, rafsanjan university of medical sciences, rafsanjan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

نادر شاهرخی | nader shahrokhi
associate professor, physiology research center, institute of neuropharmacology, department of physiology, school of medicine, ‎kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

حمید نجفی پور | hamid najafipour
professor, physiology research center, institute of neuropharmacology, department of physiology, school of medicine, kerman ‎university of medical sciences, kerman, iran


مصطفی شکوهی | mostafa shokoohi
research center for modeling in health, institute for futures studies in health, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

عبدالله جعفرزاده | abdollah jafarzadeh
professor, department of immunology, school of medicine, rafsanjan university of medical sciences, rafsanjan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

محمد کاظمی عرب آبادی | mohammad kazemi arababadi
assistant professor, department of immunology, school of medicine, rafsanjan university of medical sciences, rafsanjan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

نشانی اینترنتی http://ahj.kmu.ac.ir/ahj/index.php/ahj/article/view/218
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