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Addiction and Health، جلد ۵، شماره ۳-۴، صفحات ۸۳-۸۹
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عنوان انگلیسی The Effect of Concomitant Ethanol and Opium Consumption on Lipid Profiles and Atherosclerosis in Golden Syrian Hamster’s Aorta
چکیده انگلیسی مقاله B ackground: Cardiovascular disease (CVD) is the main cause of mortality in the world and is normally argued as the third cause of all mortalities. Opium and alcohol every day consumption can cause people to have many health problems. The present study aimed to assess the effect of ethanol and opium consumption on lipid profiles and atherosclerosis in aorta. Methods: Twenty four male golden Syrian hamsters were randomly divided into four treatment groups (n = 6): Control, addicted (40 mg/kg), alcohol (6.0 g/kg) and combination of opium and alcohol. All of the hamsters were scarified and their livers were removed immediately and fixed in formalin solution 10%. The plasma levels of the lipid profiles were measured enzymatically. Aorta sections were examined by a pathologist. Findings: The amount of the total cholesterol significantly increased in ethanol (P < 0.05) and combination (P < 0.05) groups, while it had a non-significant decrease in opium group. Serum triglyceride significantly increased in ethanol (P < 0.05) and combination (P < 0.001) groups, as well as this parameter increased in opium group but it was not significant. Low-density lipoprotein cholesterol (LDL-C) markedly increased in the combination group (P < 0.05). No significant difference was observed in serum LDL-C among other treatment groups. Levels of high-density lipoprotein cholesterol had a significant rise only in ethanol group. Change in aorta histology was not significant. Conclusion: The results showed that consumption of opium plus alcohol has harmful effects on lipid profile; however, it had no effect on aorta histology that was maybe due to the short period of the treatment.
کلیدواژه‌های انگلیسی مقاله Opium, Ethanol, Cholesterol, Atherosclerosis, Aorta
نویسندگان مقاله jahanbanoo شهریاری | jahanbanoo shahryari
assistant professor, department of pathology, neuroscience research center, institute of neuropharmacology, afzalipoor medical college, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

معین poormorteza | moein poormorteza
general practitioner, physiology research center, institute of neuropharmacology, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

آرش نوری سرخانی | arash noori sorkhani
physiology research center, institute of neuropharmacology, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

کورس دیوسالار | kouros divsalar
senior researcher, neuroscience research center, institute of neuropharmacology, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

ابراهیم عباسی عشاقی | ebrahim abbasi oshaghi
department of biochemistry, school of medicine, hamadan university of medical sciences, hamadan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

نشانی اینترنتی http://ahj.kmu.ac.ir/ahj/index.php/ahj/article/view/138
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