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Journal of Nanostructures، جلد ۱۴، شماره ۲، صفحات ۳۷۸-۳۹۱
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عنوان انگلیسی Mechanism of Preparation of Azo Dyes Derived from Cephalosporin by Chromogenic Reagent and Use of Synthesized Nano-Polymers Surface as an Adsorbent model for Future Work of Water Treatment
چکیده انگلیسی مقاله In this study, preparation of azo dyes as appropriate functional azo groups. Then pointed out best chemical properties of azo dyes by Mechanism preparation of Azo dye derived from Cephalosporin (Ceftazidime and Cefotaxime) and application in Pure Pharmaceutical dosage. Also in this study , synthesized  poly (AM-co-AC) hydrogel by free radical copolymerization, was utilized as an initiator for the free radical reaction in the presence of a catalyst, potassium persulfate (KPS), and N,N-methylene-bis-acrylamide (MBA) as crosslinking agent. The overlay nanopolymer was diagnosed utilized techniques, like FESEM, TEM and XRD measurements, this surface have a properties could be applied for future work of water treatment. Precision, selective, rapid, sensitive, inexpensive, and accurate spectrophotometric method has been developed for the study of cefotaxime in pure pharmaceutical dosage. The oxidative coupling reaction of the cefotaxime drug with 2,4-dinitrophenyl hydrazine in potassium periodate as a chromogenic reagent in alkaline medium to preparation of azo dye form a color-stable orang product soluble in water with a maximum λmax of 580 nm for two drug (Ceftazidime and Cefotaxime). The best conditions for the estimation were established, like the effect of volume of the reagent, the order of additions, the effect of volume of sodium hydroxide, the effect of temperature, the effect of solvent, and the effect of oxidation time. That obeyed law lambert beer in linearity of the concentration (1–10 mg/L) of cefotaxime, correlation coefficient of R2 (0.9979), (0.9689) and LOD( 1.2×10-4 μg/ml), ( 1.4×10-3 μg/ml),and   LOQ (9.2×10-4 μg/ml), LOQ (8.3×10-3μg/ml), for two drug (Ceftazidime and Cefotaxime) respectively. The value of recovery% was in the range of 99.16–100.7 (n = 3), which indicates the precision of the developed method. This method is useful successfully for the determination of for two drug (Ceftazidime and Cefotaxime) in pharmaceuticals (injection).
کلیدواژه‌های انگلیسی مقاله Azo Dye,Cefotaxime,Ceftazidime,Cephalosporin,Nano polymer,Pharmaceutical
نویسندگان مقاله Aseel M. Aljeboree |
Department of Chemistry, College of Sciences for Girls, University of Babylon, Hilla, Iraq

Zaied A. Mossa |
Department of Chemistry, College of Sciences for Girls, University of Babylon, Hilla, Iraq

Musaddak Maher Abdul Zahra |
Computer Techniques Engineering Department, College of Engineering and Technologies, Al-Mustaqbal University, Iraq

Mohammed Abd Jawad |
Department of Pharmaceutics, Al-Nisour University College, Baghdad, Iraq

Ayad Fadhil Alkaim |
Department of Chemistry, College of Sciences for Girls, University of Babylon, Hilla, Iraq

نشانی اینترنتی https://jns.kashanu.ac.ir/article_114362_e27c9432a97000853fff961fee94fa9c.pdf
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