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Iranian Journal of Medical Sciences، جلد ۴۹، شماره ۸، صفحات ۴۷۲-۴۸۶
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عنوان انگلیسی Key Focus Areas in Pouchitis Therapeutic Status: A Narrative Review
چکیده انگلیسی مقاله Pouchitis, as the most common complication after ileal pouch-anal anastomosis (IPAA), has an incidence from 7% to 46%. Pouchitis treatment still represents one of the biggest gaps of knowledge in the treatment of diseases. This review has focused on achievements and challenges in the treatment of pouchitis. A combined assessment of symptoms, endoscopic findings, histologic results, quick biomarkers, and fecal calprotectin test were determined to be valuable diagnostic criteria. Conventional therapy was described as a modification of bacterial flora, mainly with antibiotics and more recently with probiotics such as bifidobacteria, lactobacilli, and streptococci. Other therapeutic approaches such as anti-tumor necrosis factor, infliximab, adalimumab, vedolizumab, ustekinumab, tacrolimus, tofacitinib, thiopurines, corticosteroids, prolyl hydroxylase–containing enzymes, povidone-iodine, dextrose spray, fecal microbiota transplantation, herbal medicines, and leukocyte apheresis have been discussed. Changes in dietary components, and administration of complementary and alternative medicine, probiotics, and fecal transplantation in addition to conventional therapies were also shown to affect the outcome of disease. Due to the potential significant impairment in quality of life caused by pouchitis, it is essential to address the gaps in knowledge for both patients and physicians in its treatment. Therefore, well-designed and adequately powered studies should assess the optimal treatment for pouchitis. 
کلیدواژه‌های انگلیسی مقاله Pouchitis,Risk factors,diagnosis,Surgery,Treatment
نویسندگان مقاله Seyed Mohammad Kazem Hosseini-Asl |
Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Golnoush Mehrabani |
School of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada

Seyed Jalil Masoumi |
Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Science, Shiraz, Iran

نشانی اینترنتی https://ijms.sums.ac.ir/article_50229_e03aefec9bccb62c3e945a44b2dc16fe.pdf
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