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Iranian Journal of Materials Science and Engineering، جلد ۲۱، شماره ۳، صفحات ۱-۱۰
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عنوان انگلیسی Biogenic Synthesis of Papain Conjugated Copper Metallic Nanoparticles and Its Antibacterial and Antifungal Activity
چکیده انگلیسی مقاله Biogenic synthesis of papain-conjugated copper metallic Nanoparticles and their antibacterial and antifungal activities Papain metallic conjugated nanoparticles (Papain-CuNPs) were synthesised using Papain and CuSO4.5H2O. Papain-CuNPs were characterized using UV-visible spectroscopy, FT-IR, HR-TEM, XRD, FE-SEM, zeta potential, and a zeta sizer. The antibacterial activity of papain-CuNPs against human infectious microorganisms (Citrobacter spp, Pseudomonas aeruginosa and Candida albicans) was investigated. The mechanism of action of papain-CuNPs was evaluated using FE-SEM and HRTM. UV spectroscopy confirmed the plasma resonance (SPR) at 679 nm, which indicated the formation of papain-CuNPs. The FT-IR spectrum absorbance peaks at 3927, 3865, 3842, 3363, 2978, and 2900 cm-1 indicate the presence of O-H and N-H of the secondary amine, and peaks at 1643 and 1572 cm-1 represent C=O functional groups in Papain-CuNPs. EDAX analysis confirmed the presence of copper in the papain-CuNPs. The zeta potential (-42.6 mV) and zeta size (99.66 d. nm) confirmed the stability and size of the nanoparticles. XRD confirmed the crystalline nature of the papain-CuNPs. FE-SEM and HRTM showed an oval structure, and the nano particles' 16.71244–34.84793 nm. The synthesized papain-NPs showed significant antibacterial activity against clinical P. aeruginosa (15 mm). MIC 125 µg/ml) showed bactericidal activity against P. aeruginosa and the mechanism of action of Papain-NPs was confirmed using an electron microscope by observing cell damage and cell shrinking. Papain-CuNPs have significant antibacterial activity and are thus used in the treatment of P. aeruginosa infections
کلیدواژه‌های انگلیسی مقاله Papain,Copper sulphate,Nanoparticles,SE-SEM,HRTEM
نویسندگان مقاله | Muddukrishnaiah Kotakonda
Department of Pharmacy, Jamia Salafiya Pharmacy College, Pulikkal, Malapuram District, Kerala, India.


| Sajisha V.S
Department of Pharmaceutics, JDT Islam College of pharmacy, Jamiath Hill, Marikunnu P O, Calicut, Kerala, India.


| Aiswarya G
Department of Pharmaceutics, JDT Islam College of pharmacy, Jamiath Hill, Marikunnu P O, Calicut, Kerala, India.


| Safeela Nasrin Pakkiyan
Department of Pharmacy, Jamia Salafiya Pharmacy College, Pulikkal, Malapuram District, Kerala, India.


| Najamol A Alungal
Department of Pharmacy, Jamia Salafiya Pharmacy College, Pulikkal, Malappuram District, Kerala, India.


| Mayoora Kiliyankandi K
Department of Pharmacy, Jamia Salafiya Pharmacy College, Pulikkal, Malappuram District, Kerala, India.


| Divya Thekke Kareth
Department of Pharmacy, Jamia Salafiya Pharmacy College, Pulikkal, Malappuram District, Kerala, India.


| Naheeda Ashraf Verali Parambil
Department of Pharmacy, Jamia Salafiya Pharmacy College, Pulikkal, Malappuram District, Kerala, India.


| Saranya Sasi Mohan
Department of Pharmacy, Jamia Salafiya Pharmacy College, Pulikkal, Malappuram District, Kerala, India.


| Renjini Anil Sheeba
Department of Pharmacy, Jamia Salafiya Pharmacy College, Pulikkal, Malappuram District, Kerala, India.


| Sarika Puthiya Veettil
Department of Pharmacy, Jamia Salafiya Pharmacy College, Pulikkal, Malappuram District, Kerala, India.


| Dhanish Joseph
Department of Pharmaceutics, Nirmala College of Pharmacy, Muvattupuzha P.O Ernakulam District Kerala, India


| Nishad Kakkattummal
Department of Pharmacy, Jamia Salafiya Pharmacy College, Pulikkal, Malappuram District, Kerala, India.


| Afsal Bin Haleem MP
Department of Pharmacy, Sanjo College of Pharmaceutical Studies, Vellapara, Palakkad, Kerala, India.


| Safeera Mayyeri
Department of Pharmacy, Jamia Salafiya Pharmacy College, Pulikkal, Malappuram District, Kerala, India.


| Thasneem Chemban Koyilott
Department of Pharmacy, Jamia Salafiya Pharmacy College, Pulikkal, Malappuram District, Kerala, India.


| Nasiya Nalakath
Department of Pharmacy, Jamia Salafiya Pharmacy College, Pulikkal, Malappuram District, Kerala, India.


| Samuel Thavamani B
Department of Pharmacognosy, Ahalia School of Pharmacy, Ahalia Campus, Kozhipara, Palakkad, Kerala, India


| Famila Rani J
Department of Pharmaceutical Chemistry, JKKN College of Pharmacy, Komarapalayam. Salem, Tamil Nadu


| Aruna Periyasamy
Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, Chidambaram Tami Nadu, India.


| Chellappa V Rajesh
Department of Pharmaceutics, United College of Pharmacy, Coimbatore, Tamil Nadu, India.


| Rameswari Shanmugam
Department of Pharmaceutical Chemistry, Sree Sastha Pharmacy College, Chembarambakkam, Tamil Nadu, India.


| Marimuthu Poornima
Department of Pharmaceutical Chemistry, Sree Sastha Pharmacy College, Chembarambakkam, Tamil Nadu, India.


| Tina Raju
Department of Pharmaceutics, DM WIMS College of Pharmacy, Wayanad, Kerala, India


| Roshni E R
Department of Pharmacy, Sanjo College of Pharmaceutical Studies, Vellapara, Palakkad, Kerala, India.
نشانی اینترنتی http://ijmse.iust.ac.ir/browse.php?a_code=A-10-5284-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Biomaterials
نوع مقاله منتشر شده Research Paper
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