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Iranian Journal of Chemistry and Chemical Engineering، جلد ۴۳، شماره ۳، صفحات ۹۳۵-۹۴۵
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عنوان انگلیسی Synthesis and Characterization of Targeted Magnetic Bentonite Nanohybrid for Enhanced Drug Delivery: A Promising Approach for Cancer Therapy
چکیده انگلیسی مقاله The use of smart materials to deliver anticancer drugs to tumors has been considerably increased in cancer therapy. In this work, a novel pH-responsive system for drug delivery is proposed that employs magnetite nanoparticles and bentonite loaded with doxorubicin (DOX), a known anticancer drug, to investigate its loading capacity and release. This magnetic bentonite nanohybrid is first synthesized using a single-step method. The structural and spectral properties of the nano-assemblies are analyzed employing a variety of analytical methods including Fourier Transform InfraRed (FT-IR) spectroscopy, Scanning and Transmission Electron Microscopy (SEM and TEM, respectively), X-Ray Diffraction (XRD), and Vibrating Sample Magnetometer (VSM). The drug-loading capacity, entrapment, and yield are compared with different ratios of 1:1, 1:2, and 1:4 of the drug: nanohybrid to choose the best ratio. Moreover, a pH-sensitive release is measured at pH 7.4 and 5.5 with a total release of 57% and 80% after 72 h, respectively. Considering all these findings, the magnetic bentonite shows significant promise as a potential candidate for drug delivery applications targeting cancer cells.
کلیدواژه‌های انگلیسی مقاله magnetic bentonite nanohybrid,doxorubicin,Drug Delivery,Magnetite nanoparticles
نویسندگان مقاله Mohammad Asadi Tokmedash |
School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, I.R. IRAN

Zeinab Salehi |
School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, I.R. IRAN

Fatemeh Rezaeitavabe |
2Department of Civil Engineering, Ohio University, Ohio, Athens 45701, USA

Maede Mousavi |
School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, I.R. IRAN

نشانی اینترنتی https://ijcce.ac.ir/article_709477_2bc2668eb25ef9cb63b3613333bf39c4.pdf
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