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Iranian Journal of Public Health، جلد ۵۳، شماره ۸، صفحات ۱۸۶۴-۱۸۷۰
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عنوان انگلیسی Investigating the Potential Impact of CCR5-Δ32 Variant on COVID-19 Outcome: A Case-Control Study in Iranian Population
چکیده انگلیسی مقاله Background: The impact of CCR5-Δ32 on COVID-19 outcomes has been the focus of much research. This genetic variant may protect against SARS-CoV-2 infection, while others have produced conflicting results. Given the controversial results of previous research on different populations, we aimed to investigate the possible association between the CCR5-Δ32 variant and COVID-19 severity in an Iranian population. Methods: This case-control study was conducted between 25th of April till 10th of October 2021 at Rasoul Akram Hospital of Iran University of Medical Sciences, Tehran, Iran. We investigated the association between CCR5-Δ32 genotype and COVID-19 severity in 200 unrelated Iranian patients. The patients were divided into 2 groups: 100 patients with severe COVID-19 (case group) and 100 patients with mild COVID-19 (control group). Genotyping of CCR5-Δ32 was performed using the polymerase chain reaction (PCR) technique. Results: The frequency of CCR5-Δ32 allele was 11 in the case group and 16 in the control group. However, no significant association was found between this genetic variant and the clinical outcomes of COVID-19. Conclusion: The CCR5-Δ32 variant cannot serve as a reliable predictive factor for identifying individuals prone to developing severe COVID-19 in Iranian population. Additionally, targeting CCR5 would not be a viable treatment approach for COVID-19 in Iranians.
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نویسندگان مقاله | Parisa Mashayekhi
Molecular Medicine Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran


| Mir Davood Omrani
Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Asma Olhosna Amini
Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Mohammad Amin Omrani
Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Shahla Ganbari Milani
Department of Genetics, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/34152
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