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Iranian Journal of Basic Medical Sciences، جلد ۲۷، شماره ۱۰، صفحات ۱۲۶۸-۱۲۷۵
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عنوان انگلیسی Effect of mesenchymal stem cells and polyvinyl alcohol-coated selenium nanoparticles on rats with Alzheimer-like phenotypes
چکیده انگلیسی مقاله Objective(s): Mesenchymal stem cell (MSC) transplantation represents a promising approach for treating Alzheimer’s disease (AD). These stem cells, however, have a short lifespan following transplantation into recipient animals. Selenium nanoparticles, due to their size, aid in drug delivery for brain disorders. This study investigated the therapeutic effect of MSCs and polyvinyl alcohol (PVA)-coated selenium nanoparticles (SeNPs) in a rat model of AD.Materials and Methods: An Alzheimer-like phenotype was induced through intracerebroventricular (ICV) administration of streptozotocin (STZ).  Rats were assigned to five groups: control, Alz (STZ; 3 mg/kg, 10 μl, ICV), Alz+stem cell (ICV transplantation), Alz+SeNP (0.4 mg/kg, orally), and Alz+stem cell+SeNPs. The ICV administration of STZ mimicked some aspects of AD in the Alz groups. SeNPs were administrated for 30 days following STZ administration. The novel object recognition (NOR) and passive avoidance learning (PAL) tests were used to evaluate cognition and memory. Oxidative stress biomarkers and brain-derived neurotrophic factor (BDNF) were assessed by biochemical analysis, ELISA kits, and Congo red staining, respectively. Results: The combined therapy of PVA-coated SeNPs and MSC transplantation was more effective in enhancing memory reacquisition compared to either SeNPs or MSCs alone. The use of stem cells in conjunction with PVA-coated SeNPs significantly boosted anti-oxidant capacity.Conclusion: The results suggest that the joint treatment with PVA-coated SeNPs and MSCs offers considerable neuroprotection against AD in animal models.
کلیدواژه‌های انگلیسی مقاله Alzheimer disease, Memory, Polyvinyl alcohol, Selenium, Stem cells, Streptozocin
نویسندگان مقاله | Siamak Shahidi
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran


| Sara Soleimani Asl
Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Bahareh Gholamigeravand
Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Simimn Afshar
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran


| Nasrin Hashemi-Firouzi
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran


| Alireza Samzadeh-Kermani
Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran


| Mahsa Majidi
School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Kimia Amiri
School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_24564.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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