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Archives of Hygiene Sciences، جلد ۱۳، شماره ۱، صفحات ۱۰-۱۵
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چکیده فارسی مقاله
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عنوان انگلیسی Evaluation of Antimicrobial Properties of Bam Date Kernel Extract and Investigation of the Structure of Extract
چکیده انگلیسی مقاله Background & Aims: The prevalence of hospital infections, especially of bacterial origin, is increasing and uncontrollable in many countries. Controlling them, because of their damage to the health and economy, is essential. Therefore, numerous efforts have been made to find new antibiotics as suitable alternatives to current ones. This study aimed to investigate the antibacterial activity of date kernel extract against several hospital pathogens.
Materials and Methods: Acetone extract of Mozafati date kernel from Bam city was prepared by immersion method and its antibacterial effects on hospital pathogens such as Escherichia coli, Staphylococcus aureus, Salmonella enterica, Pseudomonas aeruginosa, Acinetobacter baumannii were investigated by the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and well diffusion method. Then, the structure of the obtained extract was determined by high-performance liquid chromatography (HPLC).
Results: The MIC was observed at 400 mg/mL of extract for S. aureus bacteria. In addition, the MBC of date kernel extract was 500 mg/mL for the tested bacteria, except for A. baumannii, where a decreasing trend was detected. The antibacterial activity was determined by the well diffusion method against all bacteria, and the greatest activity was observed against S. aureus with a growth inhibition zone diameter of 31 mm. The HPLC analysis showed the presence of 7 different structures, of which rutin was the most abundant.
Conclusion: This study indicates the high antibacterial effect of acetone extract of date kernel on the tested bacteria; however, further studies should be conducted on this plant as a new and powerful antibacterial agent.
 
کلیدواژه‌های انگلیسی مقاله Anti-infective agents, Plant extracts, Pathogens, Phoenix dactylifera L, Date extract, Bacterial infections
نویسندگان مقاله علی منجمی | Ali Monajjemi
Medical Student, School of Medicine, Qom University of Medical Sciences
دانشجوی پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی قم

مریم طبیبی | Maryam Tabibi
Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran
استادیار گروه میکروبیولوژی، مرکز تحقیقات سلولی و مولکولی، دانشگاه علوم پزشکی قم، قم، ایران

فاطمه خیری | Fatemeh Kheiri
Researcher, Qom University of Medical Sciences, Qom, Iran
دانشجوی پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی قم

علی رضا رسولی | Alireza Rasouli
Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran
مرکز تحقیقات سلولی و مولکولی، دانشگاه علوم پزشکی قم، قم، ایران

امیر ارسلان عسگری | Amir Arsalan Asgari
Lab of Microbiology, School of Medicine, Qom University of Medical Sciences
آزمایشگاه میکروب شناسی، دانشکده پزشکی، دانشگاه علوم پزشکی قم

غلام علی جعفری | Gholam Ali Jafari
Lab of Microbiology, School of Medicine, Qom University of Medical Sciences
دکتری میکروبیولوژی، آزمایشگاه میکروب شناسی، دانشکده پزشکی، دانشگاه علوم پزشکی قم

نشانی اینترنتی http://jhygiene.muq.ac.ir/browse.php?a_code=A-10-312-2&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Microbiology
نوع مقاله منتشر شده پژوهشی
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