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Journal of Craniomaxillofacial Research، جلد ۱۱، شماره ۱، صفحات ۲۰-۲۵
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عنوان انگلیسی Mir-148 and Mir-375 Expression in Oral Squamous Cell Carcinoma Patients with Oral Infection in Comparison with Oscc Patients without Oral Infection
چکیده انگلیسی مقاله Introduction: Oral squamous cell carcinoma is a multifactorial disease that is the sixth most common cancer worldwide. MicroRNAs have been confirmed to play a role in oral squamous cell carcinoma, acting as either oncogenes or tumor suppressor genes. This study examined the expression level and role of microR-148 and microR-375 in oral cancer. Materials and Methods: In this study, we used 30 cancer samples with infection and 30 cancer samples without infection. To analyze the expression of microRNA 375 and microRNA 148, we used real-time PCR. First, we extracted total RNA from the samples. Then, we generated cDNA from it. Finally, the obtained cDNA was used in the real-time PCR technique. Results: In cancer patients with oral infection, there was an increase in microRNA-148 expression and a decrease in microRNA-375 compared to cancer patients without oral infection. Conclusion: The downregulation of microRNA-375 and upregulation of microRNA-148 can be utilized as diagnostic biomarkers and prognostic factors in oral cancer. Keywords: Oral cancer; OSCC; Realtime pcr; MiR-148; MiR-375.
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نویسندگان مقاله | Naghmeh Bahrami
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Farzaneh Hosseini
Department of Microbiology, School of Microbiology Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran.


| Mahsa Hajmali
Department of Biotechnology, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran.


| Abdolreza Mohamadnia
Chronic Respiratory Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Mona Mohajeri Tehrani
Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Masoume Farhangiyan
Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran.
نشانی اینترنتی https://jcr.tums.ac.ir/index.php/jcr/article/view/491
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