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Journal of Craniomaxillofacial Research، جلد ۱۱، شماره ۱، صفحات ۲۶-۳۴
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عنوان انگلیسی The Cytotoxic Effect of 4 Different Wavelengths of Low-Level Laser Therapy on Squamous Cell Carcinoma
چکیده انگلیسی مقاله Introduction: Low-level laser therapy is a noninvasive method with the potential ability to change the balance of cell mediators and gene expressions. It affects cellular function resulting in beneficial clinical effects. This study aims to assess the effect of low-level light therapy (LLLT) using four different laser wavelengths on oral carcinoma cell viability in vitro. Materials and Methods: HN5 human head and neck squamous cell carcinoma cell lines (HNSCC) were cultured and irradiated using four wavelengths of blue (485nm), green (532nm), red (660nm), and near Infra-red (810nm) in a continuous mode with a dose of 1 J/cm2 (0.1W, 10sec) every 24hours for five consecutive days. Cell viability was assessed by evaluating mitochondrial activity by MTT assay. Results: All the wavelengths resulted in reduced viability of these cells compared to the controls. (P<0.05) There were statistically significant differences in cell viability between different wavelengths (P<0.001). The 810nm laser irradiation showed the highest percentage of cell survival (55.92%) while 660nm induced the lowest (36.02%). Conclusion: Different laser wavelengths may result in different effects on irradiated cells and red irradiation showed the lowest cell viability and the infrared laser had the highest cell viability results. Keywords: Low-level laser therapy; LLLT; Head and neck squamous cell carcinomas; HNSCC.
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نویسندگان مقاله | Arghavan Tonkaboni
Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran; Grupo De Investigacion En Patologia Oral Medico Quirurgica, Universidade De Santiago De Compostela, Santiago De Compostela, Spain.


| Alten Tatar
International Campus, School of Dentistry, Tehran University of Medical Science, Tehran, Iran.


| Kimia Hafezi Motlagh
Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.


| Reza Fekrazad
Radiation Sciences Research Center, Laser Research Center in Medical Sciences, AJA University of Medical Sciences, Tehran, Iran.
نشانی اینترنتی https://jcr.tums.ac.ir/index.php/jcr/article/view/477
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