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Iranian Journal of Pediatric Hematology and Oncology، جلد ۱۴، شماره ۳، صفحات ۲۱۷-۲۲۶
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عنوان انگلیسی Evaluating the expression of LKB1, SHMT1, and GLDC genes in Acute Lymphoblastic Leukemia patients
چکیده انگلیسی مقاله
Background: Epigenetic changes in cancer cells have an immense effect on tumorigenesis. As a tumor suppressor and an epigenetic regulator, liver kinase B1 (LKB1) reduces gene methylation by downregulating metabolic pathways such as the serine-glycine pathway. This study seeks to examine the gene expression levels of serine hydroxymethyltransferase 1 (SHMT1) and glycine decarboxylase (GLDC), as two serine-glycine pathway regulatory genes, along with LKB1 in acute lymphoblastic leukemia (ALL) patients.
Materials and Methods: In this analytical study, qRT-PCR was used to evaluate the gene expression levels of LKB1, SHMT1, and GLDC in 50 ALL patients with an average age of 11.64 ± 10.6 years. The patients were compared to 10 healthy controls. Subsequently, the correlation between the gene expression levels and the patients’ demographic data was investigated.
Results: No significant difference was found between the ALL patients and the control individuals in terms of LKB1 and GLDC gene expressions, but SHMT1 was significantly overexpressed in the ALL patients (p = 0.003). Moreover, there was a significant association between GLDC and the other SHMT1 (p = 0.020) and LKB1 (p = 0.047). No significant connection was also found between the age (pL = 0.304, pS = 0.305, pG = 0.899), gender (pL = 0.475, pS = 0.299, pG = 0.388), and blast percentage (pL = 0.335, pS = 0.148, pG = 0.459) of the patients and the genes.
Conclusion: The increased expression of SHMT1 suggests the oncogenic role of this gene. Thus, the present study offers a novel diagnostic marker in ALL patients.
کلیدواژه‌های انگلیسی مقاله Glycine dehydrogenase , Precursor cell lymphoblastic, leukemia-Lymphoma, STK11 protein
نویسندگان مقاله | Pegah Farajzadeh
Department of Genetics, Faculty of Advanced science and Technology, Tehran Medical sciences, Islamic Azad university, Tehran, Iran


| Flora Forouzesh
Assistant professor, Department of Genetics, Faculty of Advanced science and Technology, Tehran Medical sciences, Islamic Azad university, Tehran, Iran


| Maryam Nabigol
Department of Hematology and Blood Bank, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Mehdi Allahbakhshian Farsani
Department of Hematology and Blood Bank, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-1097-1&slc_lang=en&sid=1
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