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Iranian Journal of Public Health، جلد ۵۳، شماره ۹، صفحات ۲۰۷۹-۲۰۸۹
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عنوان انگلیسی The Effect of C-X-C Motif Chemokine Ligand 12 in Colorectal Cancer Associated with Chemoresistance and Radioresistance as Well as Stemness
چکیده انگلیسی مقاله Background: We aimed to explore the role of C-X-C motif chemokine ligand 12 (CXCL12) and cytokine-cytokine receptor interaction signaling pathway in the radiotherapy and chemotherapy resistance as well as cell stemness in colorectal cancer (CRC). Methods: Bioinformatics analysis was used to identify the differentially expressed mRNAs and signal pathways closely related to differentially expressed mRNAs have also been analyzed in March 2022 at the Jinhua Central Hospital, China. Then, the expression of CXCL12 was detected by qRT-PCR in colorectal cancer cells and testing the effects of transfecting CXCL12 into different CRC-derived cell lines. The effects of CXCL12 on cell proliferation were evaluated by chemosensitivity assay and radiation sensitivity assay. Results: Bioinformatics analysis of DEGs found a total of 2429 differentially expressed genes, THBS3 and CXCL12 genes are two abnormally highly expressed genes in the CRC. KEGG analysis showed the correlative signaling pathway, cytokine-cytokine receptor interaction, which is related to cell stemness. Furthermore, the expression of CXCL12 in CRC cells was detected and an increasing trend was obtained in CRC cells. In addition, the chemosensitivity and radiotherapy tolerance were elevated after transfected with CXCL12. Conclusion: CXCL12 could be a potential promote biomarkers in CRC and also promote the chemosensitivity and radiotherapy tolerance.
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نویسندگان مقاله | Wuzhen Dong
Department of Proctology, Jinhua Central Hospital, Jinhua, Zhejiang, China


| Wen Lin
Department of Nursing, Ziyang College of Dental Technology, Ziyang, Sichuan, China


| Chong Li
Department of General Surgery, The Third Affiliated Hospital of Chongqing Medical University, Shuanghu Branch Road No. 1, Yubei District, Chongqing, China
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/33462
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