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Avicenna Journal of Phytomedicine، جلد ۷، شماره ۲، صفحات ۱۸۰-۱۹۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Kidney stone formation and antioxidant effects of Cynodon dactylon decoction in male Wistar rats
چکیده انگلیسی مقاله Objectives: The antioxidant capacity impairs in kidney and urinary bladder of animals with stone disease. Herbal medicine can improve the antioxidant condition of renal tissue. Cynodon dactylon (C. dactylon) is a medicinal plant with antioxidative and diuretic properties and different preparations of this plant have shown promising effects in stone disease. Assessment of the whole plant decoction to prevent kidney stone disease as well as its antioxidant effects was the aim of this paper.Materials and Methods: Fifty male Wistar rats were randomly divided into 5 experimental groups (n=10). One group was left without treatment and four groups received ethylene glycol (1% v/v) in drinking water for 6 weeks. Three doses of Cynodon dactylon aqueous decoction (12.5, 50 and 200 mg/kg BW) were added to the drinking water of groups 3-5. Finally, water intake, 24-hour urine volume, MDA, total thiol concentration and FRAP value were measured in the serum and kidney tissues. The CaOx depositions were evaluated by hematoxylin and eosin staining.Results: Compared to the ethylene glycol-treated group, 200 mg/kg C. dactylon, lowered stone incidents, decreased urine volume, increased FRAP/g Cr (43%) and thiol content (p< 0.05) with no significant alteration of water intake, MDA decreased significantly compared to C. dactylon 12.5 (p< 0.01). Kidney weight increased and body weight decreased in ethylene glycol-treated group compared to the control group (p< 0.05). Conclusion: A minimum dose of 200 mg/kg C. dactylon reduced stone formation and simultaneously increased total antioxidant power of serum and preserved MDA content and water.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله علیرضا گلشن | alireza golshan
school of medicine, north khorasan university of medical sciences, bojnurd, iran


پریچهر hayatdavoudi | parichehr hayatdavoudi
neurocognitive research center, department of physiology, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

موسی الرضا حاج زاده | mousa al reza hadjzadeh
neurocognitive research center, department of physiology, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

ابوالفضل خواجوی راد | abolfazl khajavi rad
neurogenic inflammation research center,department of physiology, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نیما محمدیان روشن | nema mohamadian roshan
department of pathology, ghaem hospital, mashhad university of medical sciences, mashhd, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

عباسعلی عباس نژاد | abbasali abbasnezhad
department of basic sciences, faculty of medicine, gonabad university of medical sciences, gonabad,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گناباد (Gonabad university of medical sciences)

سید مجتبی موسوی | seyed mojtaba mousavi
department of physiology, school of medicine, mashhad university of medical sciences, mashhad,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

رقیه پاکدل | roghayeh pakdel
department of physiology, school of medicine, mashhad university of medical sciences, mashhad,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

بتول زارعی | batool zarei
department of physiology, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

آزیتا آقایی | azita aghaee
pharmacological research center of medicinal plants, department of pharmacology, school of medicine, mashhad university of medical sciences, mashhad,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ajp.mums.ac.ir/article_7844.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/232/article-232-323391.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research Article
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