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Avicenna Journal of Phytomedicine، جلد ۷، شماره ۲، صفحات ۱۹۱-۱۹۸
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Capparis spinosa L. aqueous extract evokes antidiabetic effect in streptozotocin-induced diabetic mice
چکیده انگلیسی مقاله Objective: As the aqueous extract of Capparis spinosa (CS) possess antidiabetic effect, he present study aims to reveal the possible mechanism of action of CS in diabetic mice.Materials and Methods: Both single and repeated oral administrations of aqueous extract of CS were performed in multi-low dose streptozotocin-induced (MLDS) diabetic mice. Euglycemic hyperinsulinemic clamp was used in association with the endogenous glucose production (perfusion rate of 3-3H glucose) to evaluate the effect of CS aqueous extract on insulin sensitivity.Results: Our study showed that aqueous extract of CS possess a potent hypoglycaemic activity in MLDS diabetic mice. Furthermore, the analysis perfusion of 3-3H glucose demonstrated the parallel decrease of basal endogenous glucose production (EGP) with the hypoglycaemic activity. EGP was lower in CS-Treated group when compared to the control group (p< 0.001). The euglycemic hyperinsulinemic clamp technique demonstrated that CS treatment improves insulin sensitivity in peripheral tissues.Conclusion: We conclude that the antihyperglycemic effet CS is probably due to the inhibition of basal endogenous glucose production and the improvement of insulin sensitivity in MLDS diabetic mice.
کلیدواژه‌های انگلیسی مقاله Diabetes, Streptozotocin, Insulin sensitivity, Mice
نویسندگان مقاله محمد eddouks | mohamed eddouks
faculty of sciences and tecniques errachidia, moulay ismail university, bp 509, boutalamine, errachidia, 52000, morocco


احمد lemhadri | ahmed lemhadri
faculty of sciences and tecniques errachidia, moulay ismail university, bp 509, boutalamine, errachidia, 52000, morocco


مراد hebi | morad hebi
faculty of sciences and tecniques errachidia, moulay ismail university, bp 509, boutalamine, errachidia, 52000, morocco


احمد el hidani | ahmed el hidani
faculty of sciences and tecniques errachidia, moulay ismail university, bp 509, boutalamine, errachidia, 52000, morocco


naoufel علی zeggwagh | naoufel ali zeggwagh
ispits rabat, avenue hassan ii km 4,5 route de casa, rabat maroc


bachir el bouhali | bachir el bouhali
faculty of sciences and tecniques errachidia, moulay ismail university, bp 509, boutalamine, errachidia, 52000, morocco


lhoussaine حاجی | lhoussaine hajji
faculty of sciences and tecniques errachidia, moulay ismail university, bp 509, boutalamine, errachidia, 52000, morocco


remy burcelin | remy burcelin
2umr 5018 cnrs-ups and ifr 31, rangueil hospital, l1 bldg, bp 84225 toulouse 31432 cedex 4, france
نشانی اینترنتی http://ajp.mums.ac.ir/article_7761.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/232/article-232-323392.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research Article
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