این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
گوارش، جلد ۲۱، شماره ۴، صفحات ۲۲۱-۰
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عنوان انگلیسی The Association between Dietary Fat Intake and Pancreatic Cancer Risk: A Large Prospective Study
چکیده انگلیسی مقاله Background Pancreatic cancer (PC) is classified as one of the most deadly cancers. Since the role of diet in modifying the effects of known risk factors of PC has been well established, exploring the dietary intakes in relation to the etiology of PC can be useful for elucidating the mechanisms of the disease progression. Methods and Materials This study was conducted within the Golestan prospective cohort study. The estimated intake of total fat and various dietary fat sources was calculated using a validated semi-quantitative food frequency questionnaire. The relationship between these dietary intakes and risk of PC was examined using Cox Regression and hazard ratio (HR) with 95% confidence interval (CI 95%) was reported. Results During 383,630 person-years follow-up and after excluding subjects with incomplete baseline information, a total of 48,676 adults were studied. Until October 30, 2014, 54 cases of PC were confirmed by medical professionals, based on the medical records and the exact cause of death using the criteria of the International Statistical Classification of Diseases and Related Health Problems 10 (ICD10). After adjusting for potential confounders we did not observe any statistically significant relationship between the intake of total fat and various dietary fat sources and risk of PC. There was only a significant positive association between the risk of PC and daily intake of butter, cream, and solid vegetable oil in the age-adjusted regression models (HR=2.10; 95% CI=1.04-4.21; P for trend=0.03). However, this relationship was not remained significant anymore in the fully adjusted models. Conclusion Based on the results of the current research, after taking into account all of the potential confounding factors, dietary intake of total fat as well as various dietary fat sources had no significant association with the risk of PC. However, it is likely that consuming substantially less saturated and trans fat sources such as dairy fats as well as solid vegetable oils may be beneficial to reduce the risk of this cancer.
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نویسندگان مقاله زینب قربانی | zeinab ghorbani
ph.d student in nutritional sciences, school of nutritional sciences and dietetics, tehran university of medical sciences tums

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

حسین پوستچی | hossein poustchi
associate professor, liver and pancreatobiliary diseases research center, digestive diseases research institute, tehranuniversity of medical sciences, tehran, iran.


اکرم پورشمس | akram pourshams
associate professor, liver and pancreatobiliary diseases research center, digestive diseases research institute, tehranuniversity of medical sciences, tehran, iran.


اکبر فاضل تبار ملکشاه | akbar fazeltabar malekshah
researcher, liver and pancreatobiliary diseases research center, digestive diseases research institute, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مریم شرفخواه | maryam sharafkhah
researcher, liver and pancreatobiliary diseases research center, digestive diseases research institute, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

دکتر آزیتا حکمت دوست | azita hekmatdoost
associate professor, department of clinical nutrition and dietetics, faculty of nutrition and food technology, national nutrition and food technology research institute, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

رضا ملک زاده | reza malekzadeh
professor, liver and pancreatobiliary diseases research center, digestive diseases research institute, tehranuniversity of medical sciences, tehran, iran
نشانی اینترنتی http://www.govaresh.org/index.php/dd/article/view/1507
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/141/article-141-323518.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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