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Molecular Biology Research Communications، جلد ۱۳، شماره ۴، صفحات ۱۹۳-۲۰۰
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عنوان انگلیسی The hepatoprotective effects of sitagliptin against cyclophosphamide-induced hepatotoxicity in rat
چکیده انگلیسی مقاله Hepatotoxicity is a serious side effects of cyclophosphamide. Thus, the present research investigates the protective properties of sitagliptin against cyclophosphamide-induced hepatotoxicity. Fifty male rats were randomly divided into five groups. They were pre-treated with either sitagliptin or normal saline once a day for the first ten days of the study. To induce acute hepatotoxicity, cyclophosphamide (200 mg/kg, i.p) was injected only one time and 45 min after the last dose of sitagliptin. The rats were sacrificed on the 11th day, and their blood and liver were collected for biochemical, gene expression, and histopathological assessments. Our results showed that cyclophosphamide induced obvious liver toxicity as marked by an increase in serum levels of alanine transaminase and aspartate transaminase, reduced serum albumin and total protein levels, in addition to histopathological changes. The malondialdehyde, tumor necrosis factor-, and interleukin-6 levels were also elevated and total antioxidant capacity declined in serum and hepatic homogenates. Sitagliptin magnificently attenuated the cylophosphamide-induced histological alterations, improved liver function tests, enhanced total antioxidant capacity, and decreased malondialdehyde, tumor necrosis factor-α, and interleukin-6 in the blood and hepatic tissues. These findings suggest that sitagliptin has hepatoprotective activity against cyclophosphamide toxicity, which may be due to its antioxidant and anti-inflammatory effects.
کلیدواژه‌های انگلیسی مقاله Cyclophosphamide, Hepatotoxicity, Oxidative stress, Sitagliptin
نویسندگان مقاله Reza Maleki |
Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

Mohammad Foad Noorbakhsh |
Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

Nasrin Kazemipour |
Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

Malihe Masudian |
Molecular Department of Central Laboratory, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

Fatemeh Namazi |
Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

Saeed Nazifi |
Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

نشانی اینترنتی https://mbrc.shirazu.ac.ir/article_7509_9a41d8247e32b121f307a762bf21c57f.pdf
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