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Iranian Journal of Pathology، جلد ۱۲، شماره ۱، صفحات ۷۹-۸۷
عنوان فارسی
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عنوان انگلیسی Inhibitory activities of platelet-rich and platelet-poor plasma on the growth- of pathogenic bacteria
چکیده انگلیسی مقاله Background:The utility and efficacy of novel materials in tissue regeneration and antimicrobial therapy are contingent upon the employment of either blood derivatives rich in platelets or platelet-poor-plasma (PPP). This effect is largely mediated by the increased or decreased concentration of platelets in the plasma. The current study aimed to analyze and evaluate the impact of platelet-rich (PRP) or PPP on inhibiting the growth of human pathogenic bacteria and compare their effects with those of chloramphenicol and penicillin. Methods: In the current comparative study, PRP–1 was generated using 1-step blood centrifugation method; whereas, for PRP–2 and PPP the 2-step centrifugation protocol was used. The antimicrobial activity of PRP–1, 2, and PPP were tested on Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa, Streptococcus agalactiae, Staphylococcus epidermidis, Shigella sp. and Serratia sp.Well diffusion and serial micro-dilution methods were used for this purpose. Chloramphenicol and penicillin susceptibility were tested using the disk diffusion method. Results: While whole blood (WB) and PPP had no discernible impact on the growth parameters of any of the bacteria tested in the current study,PRP-1 reduced the growth rate of a few selected strains. In addition, while PRP-2 clearly inhibited the growth of Shigella sp., E. coli, S. aureus, S. agalactiae, and S. epidermidis, it had no impact on the growth of K. pneumoniae, P. aeruginosa,andSerratia sp Conclusion: It can be claimed that there is a strong correlation between the concentration of platelets and the antibacterial activity of PRP.
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نویسندگان مقاله امید مقصودی |
faculty of veterinary medicine, islamic azad university, karaj branch, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

رضا رنجبر |
molecular biology research center, baqiyatallah university of medical science, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی کرج (Islamic azad university of karaj)

سید حسام الدین میرجلیلی | seyyed hesamoddin
faculty of veterinary medicine, islamic azad university, karaj branch, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

مهدی فصیحی رامندی | fasihi ramandi
molecular biology research center, baqiyatallah university of medical science, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی کرج (Islamic azad university of karaj)

نشانی اینترنتی http://ijp.iranpath.org/article_23386_081c6c54f67146769d62e225cd8122ce.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/194/article-194-323932.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده 1
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