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Veterinary Research Forum، جلد ۱۵، شماره ۹، صفحات ۴۷۳-۴۸۰
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عنوان انگلیسی Curcumin alleviates inflammatory effects of ketamine anesthesia in postnatal rats
چکیده انگلیسی مقاله Curcumin has been employed in traditional medicine for over a millennium to treat various ailments, and its global use is now widespread. Chinese medicine relies heavily on curcumin as a primary element and uses it to cure infectious diseases, skin disorders, depression, and stress. It has cardioprotective, neuroprotective, and anti-diabetic properties, as well as pharmacological effects on disorders like type II diabetes, atherosclerosis, and human immunodeficiency virus replication. The anti-cancer activity of curcumin has been studied extensively with notable improvements in gastrointestinal, melanoma, urogenital, breast, and lung malignancies. We investigated the anti-inflammatory effects of curcumin on expression of tumor necrosis factor (TNF)-α, c-Fos, and interleukin (IL)-6 genes in brain and liver tissue owing to the effects of ketamine anesthesia on postnatal rats. The thalamic and hepatic tissues were collected without anesthesia, immediately after anesthesia, and 4 and 12 hr after anesthesia in control and curcumin treated postnatal rats. The results showed that glucose, triglyceride, high- and low-density lipoprotein levels were lowered with curcumin treatment. We also found that ketamine increased c-Fos and inflammatory cytokines like TNF-α and IL-6, all of which contribute to inflammation. Brain and liver immunohistochemistry studies confirmed the real-time polymerase chain reaction findings. Curcumin injections alone may be effective in decreasing ketamine-induced inflammation in both brain and liver tissues.
کلیدواژه‌های انگلیسی مقاله brain,curcumin,Ketamine,Liver,Real-Time Polymerase Chain Reaction
نویسندگان مقاله Soroush Afshar Ghahremani |
Department of Clinical Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran

Abbas Raisi |
Department of Clinical Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran

Sohrab Minaei Beirami |
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

Houman Kahroba |
Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

Mahnaz Mardani |
Department of Health and Nutrition, Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

Omid Dezfoulian |
Department of Pathobiology, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran

Vahideh Tarhriz |
Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, USA

نشانی اینترنتی https://vrf.iranjournals.ir/article_715144_2890407e7d36207870f80731673d017d.pdf
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