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Iranian Journal of Basic Medical Sciences، جلد ۲۰، شماره ۳، صفحات ۲۵۰-۲۵۵
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عنوان انگلیسی Association between the synonymous variant organic cation transporter 3 (OCT3)-1233G>A and the glycemic response following metformin therapy in patients with type 2 diabetes
چکیده انگلیسی مقاله Objective(s): Organic cation transporter 3 (OCT3) as a high-capacity transporter contribute to the metabolism of metformin. The present study was conducted to determine the genotype frequencies of the variant OCT3-1233G>A (rs2292334) in patients with newly diagnosed type 2 diabetes (T2D) and its relationship with response to metformin. Materials and Methods: This study included 150 patients with T2D who were classified into two groups following three months of metformin therapy: responders (by more than 1% reduction in HbA1c from baseline) and nonresponders (less than 1% reduction in HbA1c from baseline). PCR-based restriction fragment length polymorphism (RFLP) served to genotype OCT3-564G>A variant. Results: The parameters such as HbA1c (P< 0.001) and BMI (P< 0.001) in both patients with GA + AA genotype and GG genotype decreased significantly following 3 months of metformin therapy compared with baseline. The mean reduction in HbA1c levels following 3 months was higher in patients with the A allele (0.77% reduction from baseline) than in those with the homozygous G allele (0.54% reduction from baseline). Also, in GA + AA genotypes compared with GG genotypes, the mean reduction in HbA1c values from baseline was 0.34% for responders and 0.14% for non-responders. Conclusion: Considering the roles of genetic variations in the function of metformin transporters, the effect of variations such as 1233G>A in the OCT3, which is a high-capacity transporter widely expressed in various tissues cannot be ignored. Comparing the allele frequencies of OCT3-1233G>A variant in our study and different ethnic populations confirm that the variant is a highly polymorphic variant.
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نویسندگان مقاله سیده راحله حسینی طالعی | seyyedeh raheleh hosseyni talei
immunogenetic research center, mazandaran university of medical sciences, sari, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

عبدالکریم مهروز | abdolkarim mahrooz
immunogenetic research center, mazandaran university of medical sciences, sari, iran|department of clinical biochemistry and genetics, faculty of medicine, mazandaran university of medical sciences, sari, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

محمد باقر هاشمی سوته | mohammad bagher hashemi soteh
immunogenetic research center, mazandaran university of medical sciences, sari, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

مریم غفاری چراتی | maryam ghaffari cherati
immunogenetic research center, mazandaran university of medical sciences, sari, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

احد علیزاده | ahad alizadeh
department of epidemiology and reproductive health, reproductive epidemiology research center, royan institute for reproductive biomedicine, acecr, tehran, iran

سازمان اصلی تایید شده: پژوهشگاه رویان (Royan institute)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_8351.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-325092.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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