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Iranian Journal of Pathology، جلد ۱۹، شماره ۳، صفحات ۳۰۶-۳۱۰
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عنوان انگلیسی Differences in CD24 Expression Between Prostate Adenocarcinoma and Benign Prostatic Hyperplasia: A Cross-sectional Study
چکیده انگلیسی مقاله Background & Objective: CD24 is a small, highly glycosylated membrane protein whose expression is associated with tumorigenesis and the progression of several types of cancer. Prostate adenocarcinoma is one of the most common cancers in men, and microscopic Gleason grading is an important factor affecting prognosis. This study aims to investigate the relationship between immunohistochemical expression of CD24 and its relationship with benign prostatic hyperplasia (BPH) and Gleason grade in prostate adenocarcinoma.
Methods: This cross-sectional study was conducted on 163 patients, with an average age of 70.63±9.05 years, including 78 (47.9%) patients with prostate adenocarcinoma and 85 (52.1%) patients with benign prostatic hyperplasia., referred to Mostafa Khomeini Hospital in Tehran between 2018 and 2021, who underwent open prostatectomy or Trans Urethral Resection of Prostate (TURP). Immunohistochemical staining was used to evaluate CD24 expression, and Gleason grade was determined in the case of prostate adenocarcinoma. Data were analyzed with SPSS 22 and a P-value<0.05 was considered statistically significant.
Results: The percentage and intensity of CD24 staining in prostate adenocarcinoma patients was significantly higher than in BPH patients (P<0.05). Gleason score strongly correlated with the percentage and intensity of CD24 staining (P<0.05). The immunoreactive score, obtained by multiplying the CD24 expression percentage with staining intensity, was also significantly related to the Gleason score (P<0.05).
Conclusion: CD24 expression can be considered as a factor in differentiating cases of prostate adenocarcinoma from benign prostatic hyperplasia. Also, a high level of this marker can indicate the progress of prostate cancer.
کلیدواژه‌های انگلیسی مقاله CD24,Prostate adenocarcinoma,Gleason grade,BPH
نویسندگان مقاله Mahdi Sajedifar |
Student Research Committee, Faculty of Medicine, Shahed University, Tehran, Iran

Atieh Jafarabadi |
Student Research Committee, Faculty of Medicine, Shahed University, Tehran, Iran

Mohammadreza Jalali Nadoushan |
Department of Pathology, Faculty of Medicine, Shahed University, Tehran, Iran

نشانی اینترنتی https://ijp.iranpath.org/article_713494_c5ec7fc86311bbb269d6eca896cc73fa.pdf
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