این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Research Journal of Pharmacognosy، جلد ۱۱، شماره ۴، صفحات ۹-۱۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Liver Protective Assessment of Garlic Oil in the Presence of Alcohol
چکیده انگلیسی مقاله Background and objectives: There is evidence that alcohol consumption is associated with liver damage. The positive role of garlic in preventing liver versus alcohol-related liver disease has been investigated before. In the present study, the possible protective role of garlic oil on the liver versus alcohol was evaluated via protein-protein interaction (PPI) network analysis to provide a new perspective of molecular events. Methods: GSE40334 from the Gene Expression Omnibus (GEO) database was selected for analysis. The significant differential expressed genes (DEGs) were determined by using the GEO2R program. UMAP analysis was applied to explore the separation of samples by analysis. Action map and gene ontology were used via Cytoscape software v 3.7.2 and its applications to find the critical DEGs and biological processes. Results: A number 798 significant DEGs were selected for analysis. The PPI network analysis showed that two clusters of DEGs play significant roles in response to garlic oil.  Ranbp2, Pafah1b1, Seh1l, Plk1, Cenpa, Mis12, and Tgfb1 as the crucial DEGs were highlighted. The biological processes related to the essential function of cells such as proliferation and cell division were identified as the regulated biological terms. Conclusion: Garlic oil plays a protective role in preventing liver damage versus consuming alcohol. Among seven crucial genes, six individuals were regulated to enhance liver health.
کلیدواژه‌های انگلیسی مقاله alcohol,Allium sativum,Garlic,Gene,Liver
نویسندگان مقاله Aliasghar Keramatinia |
Department of Community Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Reza M Robati |
Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Zahra Razzagh |
Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Babak Arjmand |
Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Amirali Aghamohammadi |
Science and Research Branch, Islamic Azad University, Tehran, Iran.

Fatemeh Bandarian |
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Farideh Razi |
Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Mostafa Rezaei Tavirani |
proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Mohammad Rostami Nejad |
Celiac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

نشانی اینترنتی https://www.rjpharmacognosy.ir/article_200256_fe761f32997a28448f2d76b2068bb424.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات